ALT-associated PML Bodies: Keys to the biology and treatment of an important subset of cancers

端粒选择性延长（ALT）是一种分子机制，约10%的癌症使用这种机制来维持它们的持续生长。ALT常见于难以治疗的肉瘤和脑肿瘤。ALT癌含有称为ALT相关PML核体（APBs）的核结构，它可能是ALT机制的一部分。这项研究将调查apb的特征及其形成方式，并将利用这些信息确定治疗ALT肿瘤的药物。

Alternative Lengthening of Telomeres (ALT) is a molecular mechanism used by ~10% of cancers to sustain their relentless growth. ALT is common in sarcomas and brain tumours which are difficult to treat. ALT cancers contain nuclear structures called ALT-associated PML nuclear bodies (APBs) which may be part of the ALT machinery. This research will investigate characteristics of APBs and how they are formed, and will use this information to identify drugs to treat ALT tumours.