Induction of senescence in cells that use the Alternative Lengthening of Telomeres (ALT) mechanism

大约10-15%的癌症依赖于端粒选择性延长（ALT）来持续生长。许多成功的癌症治疗的一个关键方面是，它们迫使癌细胞经历一种叫做衰老的永久性生长停滞。在这项研究中，我们将研究alt阳性癌细胞的特征，这些特征可能使它们特别容易衰老。这可能在未来被利用作为依赖ALT的癌症的治疗策略。

Approximately 10-15% of all cancers depend on Alternative Lengthening of Telomeres (ALT) for their continuing growth. A key aspect of many successful cancer treatments is that they force cancer cells to undergo a form of permanent growth arrest called senescence. In this study we will investigate characteristics of ALT-positive cancer cells that may make them especially vulnerable to senescence. This may be exploited in the future as a therapeutic strategy for cancers that depend on ALT.