Restoring bone regeneration in diabetic patients using ionic therapy

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Bioactive glasses (BG) release ions that influence bone regeneration. Tailoring the release of particular ions (Si, Co, Fe) may be beneficial for particular disease states (e.g. hyperglycaemia - high glucose conditions). Using multidisciplinary characterisation approaches (scanning electron microscopy (SEM), transmission electron microscopy (TEM), interferometry, Raman spectroscopy and micro-computed tomography (Mu-CT)) this project will investigate the roles of these ions on bone formation and resorption. Additionally, it will examine how the BG ions are uptaken by the cells and where they are located within laboratory-grown bone using a novel 3D in vitro model established within the research group. For this, techniques available at the synchrotron, such as extended x-ray absorption fine structure spectrometry (EXAFS), will be used.