Miniature Real-Time Volumetric Ultrasound Imaging System

微型实时体积超声成像系统

• 批准号: 6927188
• 负责人: BUTRUS T KHURI-YAKUB
• 金额: $ 46.22万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-02 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6927188
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical research; endoscopy; human subject; human therapy evaluation; imaging /visualization /scanning; neoplasm /cancer therapy; three dimensional imaging /topography; ultrasonography; ultrasound therapy

DESCRIPTION (provided by applicant): We propose to develop a miniature real-time volumetric ultrasound imaging system employing two-dimensional (2D) capacitive micromachined ultrasonic transducer (CMUT) arrays. We will design and implement a miniature probe fitting into the tip of an endoscope that will be connected to an external beamforming unit using a small number of cables. The probe will contain a 2D CMUT array and integrated circuits to handle the data acquisition and front-end pre-processing. A small-sized active phased subarray will be multiplexed over a large transducer array in consecutive firing steps to allow for real-time data acquisition. The acquired data will be transferred to the external unit and processed to form real-time pyramidal volumetric images. CMUT technology provides excellent element sensitivity, large temporal bandwidth, and potential for integrating the transducer with front-end electronic circuitry. The image reconstruction algorithm is based on phased subarray processing which allows for a low-cost front-end architecture while providing high-quality real-time images. The combination of CMUT technology and phased subarray (PSA) imaging will enable us to realize a small ultrasound scanner where the size and cost of the front-end circuitry is critical. We have achieved the following preliminary results: (1) Identified several image-guided surgical applications for cancer treatment, (2) specified the probe parameters based on physician input, (3) fabricated 128-element 1D CMUT array and (4) used it to form a high-quality 2D image, (4) fabricated a prototype 16x16-element 2D CMUT array, (5) developed PSA theory for 2D and 3D imaging, (6) tested 2D PSA theory with simulations and experimental data, and (7) shown that the system specs allow for real-time 3D ultrasound imaging. We propose to take the next major developmental step and demonstrate real-time 3D imaging from a miniature probe by accomplishing the following specific aims: (1) form preliminary 3D images using the prototype array and existing acquisition system, (2) design and fabricate new 16x16 2D CMUT arrays, (3) implement real-time beamforming and visualization, (4) design and build integrated circuits for the front-end probe electronics, (5) perform final integration into a fully function real-time 3D ultrasound system, and (6) perform preliminary clinical evaluation.

描述（由申请人提供）： 我们建议开发一个微型实时体积超声成像系统，采用二维（2D）电容式微机械超声换能器（CMUT）阵列。我们将设计和实现一个微型探头安装到内窥镜的尖端，将使用少量的电缆连接到外部波束形成单元。探头将包含一个2D CMUT阵列和集成电路，以处理数据采集和前端预处理。一个小尺寸的有源相控阵列将在一个大的换能器阵列在连续的发射步骤，以允许实时数据采集多路复用。采集的数据将被传输到外部单元并进行处理，以形成实时金字塔体积图像。CMUT技术提供了出色的元件灵敏度、大的时间带宽以及将换能器与前端电子电路集成的潜力。图像重建算法是基于相控阵处理，它允许一个低成本的前端架构，同时提供高质量的实时图像。CMUT技术和相控阵（PSA）成像的结合将使我们能够实现小型超声扫描仪，其中前端电路的尺寸和成本至关重要。 我们取得了以下初步成果：（1）确定了几种用于癌症治疗的图像引导手术应用，（2）根据医生输入指定探头参数，（3）制造128元件1D CMUT阵列，（4）使用它形成高质量2D图像，（4）制造原型16x16元件2D CMUT阵列，（5）开发了用于2D和3D成像的PSA理论，（6）用模拟和实验数据测试了2D PSA理论，以及（7）表明系统规格允许实时3D超声成像。 我们建议采取下一个主要的发展步骤，并通过实现以下具体目标来演示微型探头的实时3D成像：（1）使用原型阵列和现有采集系统形成初步3D图像，（2）设计和制造新的16 × 16 2D CMUT阵列，（3）实现实时波束形成和可视化，（4）设计和构建前端探头电子设备的集成电路，（5）最终集成到功能齐全的实时3D超声系统中，以及（6）进行初步临床评估。

项目成果

Wafer-bonded 2-D CMUT arrays incorporating through-wafer trench-isolated interconnects with a supporting frame.

晶圆键合 2-D CMUT 阵列将贯穿晶圆的沟槽隔离互连与支撑框架结合在一起。

• DOI: 10.1109/tuffc.2009.1018
• 发表时间: 2009
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Zhuang,Xuefeng;Wygant,IraO;Lin,Der-Song;Kupnik,Mario;Oralkan,Omer;Khuri-Yakub,ButrusT
• 通讯作者: Khuri-Yakub,ButrusT

Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array.

• DOI: 10.1109/tbme.2012.2183593
• 发表时间: 2012-05
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Kothapalli SR;Ma TJ;Vaithilingam S;Oralkan O;Khuri-Yakub BT;Gambhir SS
• 通讯作者: Gambhir SS