Investigating ribosome specialization during cellular differentiation

研究细胞分化过程中的核糖体特化

• 批准号: 2594329
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2594329
• 关键词: Investigating; ribosome; specialization; during; cellular

Ribosome synthesis and translation are fundamental processes that are tightly coupled to cell growth and proliferation. During differentiation of pluripotent stem cells, global translation is remodelled in a bespoke, lineage specific manner. One cog in the machinery that may mediate this process is the specialisation of ribosomes. Long thought of as being homogenous, there is mounting evidence indicating that the composition of ribosomes is not uniform. Indeed, heterogeneous ribosomes have been observed in different tissues, at different developmental stages and under stress conditions. Ribosome specialisation is a means by which gene expression can be regulated through the translation of specific subsets of mRNAs. We propose to expand our current understanding of ribosome specialization by investigating the synthesis of ribosomes in pluripotent stem cells and in different lineages following differentiation.

核糖体合成和翻译是与细胞生长和增殖紧密相关的基本过程。在多能干细胞的分化过程中，整体翻译以定制的谱系特异性方式重塑。核糖体的特化可能是介导这一过程的机器中的一个齿轮。长期以来，核糖体被认为是同质的，但越来越多的证据表明，核糖体的组成并不均匀。事实上，在不同组织、不同发育阶段和应激条件下都观察到了异质核糖体。核糖体特化是一种通过翻译特定的mRNA子集来调节基因表达的方法。我们建议通过研究多能干细胞和分化后不同谱系中核糖体的合成来扩大我们目前对核糖体特化的理解。