Improved EEG Spatial Resolution via the Normal E-field

通过正常电场提高脑电图空间分辨率

• 批准号: 6998599
• 负责人: ROBERT MATTHEWS
• 金额: $ 13.84万
• 依托单位: QUASAR, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998599
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; clinical biomedical equipment; electric field; electrical measurement; electroencephalography

DESCRIPTION (provided by applicant): Measurement of the complete 3-component electric (E-) field vector has very recently become possible through the development of sensors that can measure free-space electric potential at the sub-microvolt level. This technology has been applied to through-clothing measurement of ECG, with successful preliminary measurements for EEG and ERP. Analysis has already shown that the normal E-field, En, produced by brain sources is more tightly focused in space than the tangential field from the same source when measured through the head. The goal of Phase I is to quantify how a measurement of the E-field in the direction normal to the scalp can be applied to replace or augment conventional electric potential data collected on the scalp surface. 3 specific analysis issues of relevance for EEG, ERP brain source imaging will be investigated. Synthetic data, including sensor effects, will be generated by a sophisticated three-dimensional (3D) numerical simulation supported by analytic calculations. The benefit of measuring the E-field will be quantified by analyzing the data with and without the normal field information, using a modified form of the Brainstorm program. In Phase II, a new type of EEG electrode system that includes sensors of the normal electric field will be constructed together with algorithms that utilize the En information. The system will be directly compared with a 120- electrode Geodesic Sensor Net System on subjects participating in standard evoked potential and EEG experiments. The ability to measure the normal E-field external to the head provides an entirely separate new channel of information about the electrical sources in the brain. If successful this program will contribute to the whole art of EEG signal acquisition, providing a general advance in research and clinical measurement technology. In addition, because the method operates off the body, it should lead to greater patient comfort and facilitate non-medical applications of brain signal measurement, such as alertness monitoring and cognitive state assessment.

描述（由申请人提供）：最近，通过能够测量亚微伏级自由空间电势的传感器的开发，完整的3分量电场（E-）矢量的测量已经成为可能。该技术已应用于心电图的穿衣测量，并成功地初步测量了EEG和ERP。分析已经表明，当通过头部测量时，由大脑源产生的正常E场En在空间中比来自相同源的切向场更紧密地聚焦。第一阶段的目标是量化如何在垂直于头皮的方向上测量电场，以取代或增强在头皮表面上收集的常规电势数据。将研究与EEG、ERP脑源成像相关的3个具体分析问题。包括传感器效应在内的合成数据将通过由分析计算支持的复杂三维（3D）数值模拟生成。将使用修改后的Brainstorm程序，通过分析具有和不具有正常场信息的数据来量化测量电场的受益。在第二阶段，一种新型的EEG电极系统，包括正常电场的传感器将与利用En信息的算法一起构建。该系统将在参与标准诱发电位和EEG实验的受试者身上直接与120电极测地线传感器网络系统进行比较。测量头部外部正常电场的能力提供了一个完全独立的关于大脑中电源的新信息通道。如果成功，该计划将有助于整个艺术的脑电信号采集，提供了一个普遍的进步，在研究和临床测量技术。此外，由于该方法在身体外操作，因此它应该导致更大的患者舒适度，并促进脑信号测量的非医学应用，例如警觉性监测和认知状态评估。