Cardiac Synchronization Technology for PEA Patients

描述（由申请人提供）：无脉性电活动（PEA）也称为机电解离（EMD），已被描述为“在心电图上存在有组织的电活动，但没有可触及的脉冲”。它是许多干扰心肺功能的过程的共同终点，特别是主要的心脏损伤和缺氧引起的呼吸衰竭。绝大多数在院外环境中患有PEA的患者将无法生存。因此，对PEA进行有效的治疗是非常重要的。先前的研究表明，很大一部分PEA患者实际上还有剩余的心脏机械活动。研究小组提出了一种假设，即如果心脏按压与剩余心肌机械活动同步，结果可能会改善。换句话说，我们假设，如果定时按压以帮助射血，即在内在收缩时挤压胸部，并在内在舒张时放松以允许足够的心室充盈，则结果将得到改善。为了响应NIH项目公告（PA） 04-059 -监测和执行复苏技术，Rose生物医学发展公司提议开发和试点心脏同步技术（CST），这是一种通过同步胸腔按压和假emd PEA患者剩余心脏机械活动来改善预后的非侵入性方法。

DESCRIPTION (provided by applicant): Pulseless electrical activity (PEA) also referred to as electromechanical dissociation (EMD), has been described as "the presence of organized electrical activity on the electrocardiogram but without palpable pulses." It is the common end-point for a number of processes that interfere with cardiopulmonary function, in particular major cardiac insults and respiratory failure with hypoxia. The vast majority of patients suffering PEA in the out-of-hospital setting will not survive. Therefore, an effective treatment for PEA could be extraordinarily important. Previous research has demonstrated that a large fraction of patients in PEA actually have residual cardiac mechanical activity. The research team has developed a hypothesis that outcomes may improve if cardiac compressions are synchronized with residual myocardial mechanical activity. In other words, we hypothesize that outcomes will improve if compressions are timed to assist ejection -- squeezing the chest during intrinsic contractions -- and relaxing so as to allow adequate ventricular filling during intrinsic diastole. In response to NIH Program Announcement (PA) 04-059 - Technologies for Monitoring and Performing Resuscitation, Rose Biomedical Development Corporation proposes to develop and pilot test Cardiac Synchronization Technology (CST), a non-invasive approach to improving outcomes by synchronizing chest compression with residual cardiac mechanical activity in patients with pseudo-EMD PEA.