Cardiac Synchronization Technology for PEA Patients

适用于 PEA 患者的心脏同步技术

• 批准号: 6935528
• 负责人: JON VONOHLSEN
• 金额: $ 9.1万
• 依托单位: ROSE BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935528
• 关键词: cardiopulmonary resuscitation; heart contraction; heart electrical activity; heart rhythm; swine; technology /technique development

DESCRIPTION (provided by applicant): Pulseless electrical activity (PEA) also referred to as electromechanical dissociation (EMD), has been described as "the presence of organized electrical activity on the electrocardiogram but without palpable pulses." It is the common end-point for a number of processes that interfere with cardiopulmonary function, in particular major cardiac insults and respiratory failure with hypoxia. The vast majority of patients suffering PEA in the out-of-hospital setting will not survive. Therefore, an effective treatment for PEA could be extraordinarily important. Previous research has demonstrated that a large fraction of patients in PEA actually have residual cardiac mechanical activity. The research team has developed a hypothesis that outcomes may improve if cardiac compressions are synchronized with residual myocardial mechanical activity. In other words, we hypothesize that outcomes will improve if compressions are timed to assist ejection -- squeezing the chest during intrinsic contractions -- and relaxing so as to allow adequate ventricular filling during intrinsic diastole. In response to NIH Program Announcement (PA) 04-059 - Technologies for Monitoring and Performing Resuscitation, Rose Biomedical Development Corporation proposes to develop and pilot test Cardiac Synchronization Technology (CST), a non-invasive approach to improving outcomes by synchronizing chest compression with residual cardiac mechanical activity in patients with pseudo-EMD PEA.

描述(由申请人提供)：无脉搏电活动(PEA)，也称为机电分离(EMD)，已被描述为“在心电图上存在有组织的电活动，但没有可触摸到的脉冲。”它是许多干扰心肺功能的过程的共同终点，特别是严重的心脏损伤和缺氧引起的呼吸衰竭。绝大多数在医院外环境中遭受PEA的患者将无法存活。因此，对PEA进行有效的治疗可能非常重要。先前的研究已经证明，PEA中的很大一部分患者实际上存在残余的心脏机械活动。研究小组提出了一个假设，即如果心脏按压与残余心肌机械活动同步，结果可能会改善。换句话说，我们假设，如果按压的时机能帮助射血--在内在收缩时挤压胸部--并放松，以便在内在舒张期有足够的脑室充盈，那么结果将会改善。为了回应美国国立卫生研究院项目公告(PA)04-059--监测和实施复苏技术，Rose Biomedical Development Corporation建议开发和试点心脏同步技术(CST)，这是一种非侵入性方法，通过同步胸部按压和假性EMD PEA患者的残余心脏机械活动来改善预后。