DETECTION SYSTEM FOR REFRACTIVE SURGERY IN DONOR EYES

描述（由申请人提供）：Vision Optimization正在提交I期SBIR，以开发和验证一种简单、快速、可靠和敏感的软件检测工具，该工具基于角膜地形，将识别以前接受过激光屈光手术的人类供体眼睛。该技术必须是非侵入性的，并且不需要过度地操作眼球。此外，它必须能够“在现场”，在捐赠者床边获得，因为在美国大约有一半的眼睛是作为角膜-巩膜边缘原位切除的，而不是整个眼球。角膜地形学目前由许多用于形状分析的技术和表面表示组成，包括基于表面高度的系统，以及基于斜率的曲率系统。每种技术都有各自的优势，我们的软件产品将适应多种技术。

DESCRIPTION (provided by applicant): Vision Optimization is submitting a Phase I SBIR to develop and validate a simple, rapid, reliable, and sensitive software detection tool, based on corneal topography that will identify human donor eyes that have had previous laser refractive surgery. The technique must be noninvasive and must not require excessive manipulation of the globe. In addition, it must be amenable to acquisition "in the field," at the donor bedside, since approximately half of eyes in the U.S. are excised in situ as corneo-scleral rims, rather than whole globes. Corneal topography currently consists of many technologies and surface representations for shape analysis, including surface height-based systems, as well as slope-based curvature systems. Each technology has individual advantages and our software product will be adaptable to multiple technologies. Phase I of this submission will have 2 objectives. The first objective is to create a software product that takes conreal topographic maps as inputs and produces a prediction as to the presence of previous refractive surgeries. The second objective is to quantitatively very to operation of the software on a serious of topographic maps with theoretical representations of non-refractive surgery corneas, post-myopic refractive surgery eyes and post-hyperopic/keratoconic refractive surgery eyes. A future Phase II grant application will seek to further validate this software through additional studies consisting of a retrospective study on living refractive surgery patients and prospectively through a series of donor eyes collected as part of the grant. Further development in Phase III will seek preparation of the product for release and sale as well as exploring further markets such as military pilot flight screening.