DETECTION SYSTEM FOR REFRACTIVE SURGERY IN DONOR EYES

用于供体眼睛屈光手术的检测系统

• 批准号: 6934871
• 负责人: JAMES R MAROUS
• 金额: $ 9.74万
• 依托单位: VISION OPTIMIZATION, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6934871
• 关键词: computer assisted medical decision making; computer program /software; computer system design /evaluation; cornea; eye laser surgery; eye transplantation; postoperative state; tissue donors

DESCRIPTION (provided by applicant): Vision Optimization is submitting a Phase I SBIR to develop and validate a simple, rapid, reliable, and sensitive software detection tool, based on corneal topography that will identify human donor eyes that have had previous laser refractive surgery. The technique must be noninvasive and must not require excessive manipulation of the globe. In addition, it must be amenable to acquisition "in the field," at the donor bedside, since approximately half of eyes in the U.S. are excised in situ as corneo-scleral rims, rather than whole globes. Corneal topography currently consists of many technologies and surface representations for shape analysis, including surface height-based systems, as well as slope-based curvature systems. Each technology has individual advantages and our software product will be adaptable to multiple technologies. Phase I of this submission will have 2 objectives. The first objective is to create a software product that takes conreal topographic maps as inputs and produces a prediction as to the presence of previous refractive surgeries. The second objective is to quantitatively very to operation of the software on a serious of topographic maps with theoretical representations of non-refractive surgery corneas, post-myopic refractive surgery eyes and post-hyperopic/keratoconic refractive surgery eyes. A future Phase II grant application will seek to further validate this software through additional studies consisting of a retrospective study on living refractive surgery patients and prospectively through a series of donor eyes collected as part of the grant. Further development in Phase III will seek preparation of the product for release and sale as well as exploring further markets such as military pilot flight screening.

描述（由申请人提供）：Vision Optimization正在提交一项I期SBIR，以开发和验证一种简单、快速、可靠和灵敏的软件检测工具，该工具基于角膜地形图，将识别既往接受过激光屈光手术的人类供体眼睛。该技术必须是非侵入性的，并且不得需要过度操作地球仪。此外，它必须能够在供体床边“现场”采集，因为在美国大约有一半的眼睛是作为角膜巩膜缘而不是整个眼球原位切除的。角膜地形图目前包括许多技术和表面表示的形状分析，包括表面高度为基础的系统，以及基于斜率的曲率系统。每种技术都有各自的优势，我们的软件产品将适应多种技术。 本次提交的第I阶段将有2个目标。第一个目标是创建一个软件产品，该软件产品将conreal地形图作为输入，并预测先前屈光手术的存在。第二个目标是定量地非常软件在一系列地形图上的操作，这些地形图具有非屈光手术角膜、近视后屈光手术眼睛和远视/圆锥角膜屈光手术眼睛的理论表示。 未来的第二阶段赠款申请将寻求通过额外的研究进一步验证该软件，这些研究包括对活体屈光手术患者的回顾性研究，以及作为赠款一部分收集的一系列供体眼睛的前瞻性研究。 第三阶段的进一步发展将寻求产品的发布和销售的准备，以及探索进一步的市场，如军事飞行员飞行筛选。