Implantable PV ECG Telemetry System

植入式光伏心电图遥测系统

• 批准号: 6932889
• 负责人: HUNTLY D MILLAR
• 金额: $ 10万
• 依托单位: MILLAR, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932889
• 关键词: biomedical device power system; biomedical equipment development; cardiovascular function; electrocardiography; heart catheterization; implant; medical implant science; miniature biomedical equipment; telemetry

DESCRIPTION (provided by applicant): Animal research is of vital importance to studies of human diseases. Research in transgenic mice is cost-effective and is becoming a screening standard at the FDA. The proposed research will develop a small animal-implantable cardiac physiology research monitor, with high fidelity pressure-volume and ECG sensors mounted on a 1F catheter. Cardiovascular parameters will be transmitted to an external data collection module for up to 3 months. The system will be catheter-based, specifically designed for cardiovascular research, but could be applied to any organ research, including the brain, the bladder, and major blood vessels. The system is designed to allow a mouse to return to a normal physiological state after implantation. Phase I will develop and evaluate vacuum-sealed ultra-miniature pressure transducers and control circuitry using a pulsatile mouse heart simulator. The standardization and temperature compensation will be achieved using either laser-trimmed resistors or signal conditioning CMOS technology. Implant life will be maximized by applying pulsed excitation techniques. A complete prototype system will be tested. Phase II will miniaturize the implanted package, and test it in animals. Studies will include optimization of data sampling rates, operational life, and characterization of tissue-device interaction at gross and histological levels.

描述(由申请人提供)： 动物研究对人类疾病的研究至关重要。转基因小鼠的研究具有成本效益，并正在成为FDA的筛选标准。这项拟议的研究将开发一种小型动物植入型心脏生理学研究监测器，将高保真压力-体积和心电传感器安装在1F导管上。心血管参数将被传输到外部数据收集模块，最长可达3个月。该系统将以导管为基础，专门为心血管研究设计，但可以应用于任何器官研究，包括大脑、膀胱和主要血管。该系统的设计目的是让小鼠在植入后恢复正常的生理状态。 第一阶段将使用脉动的小鼠心脏模拟器开发和评估真空密封的超小型压力传感器和控制电路。标准化和温度补偿将使用激光微调电阻或信号调理CMOS技术来实现。通过应用脉冲激励技术，植入物的寿命将最大化。一个完整的原型系统将进行测试。第二阶段将植入的包装微型化，并在动物身上进行测试。研究将包括数据采样率、使用寿命的优化，以及大体和组织学水平上组织-装置相互作用的特征。