Miniaturization of Catheters and Pressure Sensors

导管和压力传感器的小型化

• 批准号: 6892073
• 负责人: HUNTLY D MILLAR
• 金额: $ 27.78万
• 依托单位: MILLAR, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6892073
• 关键词: artery; biomedical equipment development; biosensor device; blood pressure; catheterization; genetically modified animals; heart function; heart rate; laboratory mouse; miniature biomedical equipment

DESCRIPTION (provided by applicant): This project is to develop an ultra-miniature catheter-tip pressure transducer to be mounted in a catheter suitable for use in transgenic mice weighing twenty grams or less. The initial prototype transducer will be 1.OF (0.33 mm OD) in diameter, which has been modeled under the Phase I project. A smaller diameter transducer will be developed in this Phase II effort. The sensor will have a high frequency response sufficient for accurate reproduction of transgenic mouse blood pressure waveforms, at heart rates of up to 1,000 beats per minute with pressure change rates of up to 20,000 mmHg per second. The high-fidelity ultra-miniature catheter will enable researchers to investigate mouse hemodynamics throughout the cardiovascular system, including renal arteries. A femoral approach will now be possible, similar to the procedure used in human cardiac catheterizations. Since many forms of heart disease are caused by or affected by genetic factors, the transgenic mouse is the research animal of choice. Investigations of genes active in juvenile mice but not in adult mice will now be possible with access to smaller arteries. A more complete description of the effect of a single gene on the cardiovascular system would further the search for cures of these diseases, the leading cause of death in America.

描述（由申请人提供）：本项目是开发一种超小型导管尖端压力传感器，安装在导管中，适用于体重不超过20克的转基因小鼠。最初的原型传感器将是1。OF （0.33 mm外径）直径，已在一期项目中建模。第二阶段将开发一种直径更小的换能器。该传感器将具有高频率响应，足以精确再现转基因小鼠的血压波形，心率高达每分钟1,000次，压力变化率高达每秒20,000 mmHg。这种高保真的超微型导管将使研究人员能够研究小鼠整个心血管系统的血流动力学，包括肾动脉。股骨入路现在将成为可能，类似于人类心导管插入术。由于许多形式的心脏病是由遗传因素引起或受遗传因素影响的，转基因小鼠是首选的研究动物。现在有了更小的动脉，研究在幼年小鼠而不是成年小鼠中活跃的基因将成为可能。更完整地描述单个基因对心血管系统的影响，将进一步探索这些疾病的治疗方法，这些疾病是美国人死亡的主要原因。