Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
基本信息
- 批准号:6837641
- 负责人:
- 金额:$ 24.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-01-01 至 2007-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The long-term objective of this research program is to advance the practice of complex molecule synthesis. Special emphasis is placed on natural products that contain nitrogen since an unusually large number of pharmacologically active compounds incorporate this element within their structure. Despite the many advances in organic synthesis in the past 20th century the efficient and economical synthesis of complex natural products remains a challenging endeavor. Our plan is to introduce new inexpensive building blocks to the field of organic synthesis for use in asymmetric synthesis of nitrogen heterocycles. These building blocks would expedite the chemical synthesis of the rare marine alkaloid upenamide, the stemona alkaloids and 2-substituted piperidine alkaloids. We also present a plan for the synthesis of Iomaiviticins A and B, secondary metabolites isolated from fermentation of a marine derived actinomycetes. Lomaiviticins A and B are potent antibiotics against Gram-positive bacteria Staphylococcus aureus and Enterococcus faecium (MIC 6-25 ng/spot). An unusual structural feature of the Iomaiviticins is the incorporation of two diazo groups within their structure.
描述(由申请人提供):本研究计划的长期目标是推进复杂分子合成的实践。特别强调的是含有氮的天然产物,因为异常大量的生物活性化合物在其结构中含有这种元素。尽管有机合成在过去的世纪取得了许多进展,但复杂天然产物的有效和经济的合成仍然是一项具有挑战性的奋进。我们的计划是引入新的廉价的有机合成领域的氮杂环化合物的不对称合成使用的积木。这些结构单元将加速稀有海洋生物碱乌本酰胺、百部生物碱和2-取代哌啶生物碱的化学合成。我们还提出了一个计划,为Iomaiviticins A和B,从海洋来源的放线菌发酵分离的次级代谢产物的合成。洛麦维他菌素A和B是针对革兰氏阳性菌金黄色葡萄球菌和屎肠球菌的有效抗生素(MIC 6-25 ng/斑点)。Iomaiviticins的一个不寻常的结构特征是在其结构中掺入两个重氮基团。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GARY ALLEN SULIKOWSKI其他文献
GARY ALLEN SULIKOWSKI的其他文献
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{{ truncateString('GARY ALLEN SULIKOWSKI', 18)}}的其他基金
Chemistry and Biology of Novel Arachidonic Acid Metabolites
新型花生四烯酸代谢物的化学和生物学
- 批准号:
8944947 - 财政年份:2015
- 资助金额:
$ 24.16万 - 项目类别:
Chemistry and Biology of Novel Arachidonic Acid Metabolites
新型花生四烯酸代谢物的化学和生物学
- 批准号:
9257449 - 财政年份:2015
- 资助金额:
$ 24.16万 - 项目类别:
Chemistry and Biology of Novel Arachidonic Acid Metabolites
新型花生四烯酸代谢物的化学和生物学
- 批准号:
9100884 - 财政年份:2015
- 资助金额:
$ 24.16万 - 项目类别:
Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
- 批准号:
7340231 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
- 批准号:
6998859 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
- 批准号:
7241965 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
- 批准号:
7157615 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
- 批准号:
6969819 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
Strategies and Tactics for Natural Products Synthesis
天然产物合成的策略和策略
- 批准号:
6720884 - 财政年份:2004
- 资助金额:
$ 24.16万 - 项目类别:
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