Nitric Oxide Regulation of Platelet Granule Exocytosis
一氧化氮对血小板颗粒胞吐作用的调节
基本信息
- 批准号:6836475
- 负责人:
- 金额:$ 11.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-12-22 至 2008-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
I am applying for a Mentored Clinical Scientist Career Award (K08) in order to gain mentored basic research training. I wish to investigate nitric oxide regulation of platelet granule exocytosis as it relates to thrombosis. Through this award I seek to become an investigator capable of applying my knowledge and training through 1) a mentored laboratory-based component to acquire knowledge in (a) exocytosis research and (b) thrombosis research; 2) a comparative medicine-based component; 3) an advisory committee; and 4) a general Johns Hopkins Medical Institute-based component. Research mentorship will be provided by Dr. Charles Lowenstein, a cardiologist and an expert in nitric oxide (NO) and NO synthase research. In particular, his laboratory explores mechanisms by which NO regulates vascular inflammation.
My specific research proposal is aimed at defining the role of NO in regulating platelet granule exocytosis. In particular, I am interested in NO modification of the molecule N-ethylmaleimide sensitive factor (NSF), a molecule involved in regulating exocytosis in many cell types. My specific aims are intended to demonstrate that: 1) NO regulates platelet granule exocytosis: 2) NO regulates NSF activity in vitro and in vivo; and 3) peptide inhibitors of NSF inhibit NSF in vitro and therefore inhibit thrombosis in vivo.
Vascular inflammation is an important component of many cardiovascular diseases. Platelet-derived prothrombotic and inflammatory mediators, such as those found in platelet granules, are key in promoting localization of platelets and leukocytes (neutrophils, in particular) to the sites of vascular injury and may exacerbate the injury. Therefore, strategies to minimize granule exocytosis may prove valuable in the acute treatment of pro-thrombotic diseases. (End of Abstract)
描述(由申请人提供):
我正在申请指导临床科学家职业奖(K 08),以获得指导基础研究培训。 我希望研究一氧化氮对血小板颗粒胞吐作用的调节,因为它与血栓形成有关。 通过这个奖项,我希望成为一名能够通过以下方式应用我的知识和培训的研究员:1)以实验室为基础的指导组件,以获得(a)胞吐研究和(B)血栓形成研究方面的知识; 2)以比较医学为基础的组件; 3)咨询委员会;以及4)以约翰霍普金斯医学研究所为基础的组件。 研究指导将由心脏病专家、一氧化氮(NO)和NO合酶研究专家Charles Lowenstein博士提供。 特别是,他的实验室探索了NO调节血管炎症的机制。
我的具体研究计划旨在确定NO在调节血小板颗粒胞吐中的作用。 特别是,我感兴趣的是NO修饰的分子N-乙基马来酰亚胺敏感因子(NSF),参与调节胞吐在许多细胞类型的分子。 我的具体目标是证明:1)NO调节血小板颗粒胞吐作用; 2)NO调节体外和体内NSF活性; 3)NSF的肽抑制剂在体外抑制NSF,从而抑制体内血栓形成。
血管炎症是许多心血管疾病的重要组成部分。 血小板衍生的血栓前介质和炎症介质,例如在血小板颗粒中发现的那些,是促进血小板和白细胞(特别是中性粒细胞)定位于血管损伤部位的关键,并可能加重损伤。 因此,减少颗粒胞吐的策略可能在血栓前疾病的急性治疗中证明是有价值的。 (End摘要)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CRAIG N MORRELL其他文献
CRAIG N MORRELL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CRAIG N MORRELL', 18)}}的其他基金
Platelet-Regulated Immune Responses in Neonates Following Transfusion
新生儿输血后血小板调节的免疫反应
- 批准号:
10217253 - 财政年份:2020
- 资助金额:
$ 11.76万 - 项目类别:
Platelet-Regulated Immune Responses in Neonates Following Transfusion
新生儿输血后血小板调节的免疫反应
- 批准号:
10039184 - 财政年份:2020
- 资助金额:
$ 11.76万 - 项目类别:
ERK5 and CD36 link oxidative stress to platelet dysfunction and ischemic injury
ERK5 和 CD36 将氧化应激与血小板功能障碍和缺血性损伤联系起来
- 批准号:
10323025 - 财政年份:2019
- 资助金额:
$ 11.76万 - 项目类别:
Novel mechanisms of platelet modified monocyte phenotype
血小板修饰单核细胞表型的新机制
- 批准号:
10166903 - 财政年份:2018
- 资助金额:
$ 11.76万 - 项目类别:
Novel mechanisms of platelet modified monocyte phenotype
血小板修饰单核细胞表型的新机制
- 批准号:
10377113 - 财政年份:2018
- 资助金额:
$ 11.76万 - 项目类别:
Novel platelet functions for in T-cell helper cell responses
T 细胞辅助细胞反应中的血小板新功能
- 批准号:
9385749 - 财政年份:2014
- 资助金额:
$ 11.76万 - 项目类别:
Novel platelet functions for in T-cell helper cell responses
T 细胞辅助细胞反应中的血小板新功能
- 批准号:
8967578 - 财政年份:2014
- 资助金额:
$ 11.76万 - 项目类别:
相似海外基金
FAIRClinical: FAIR-ification of Supplementary Data to Support Clinical Research
FAIRClinical:补充数据的 FAIR 化以支持临床研究
- 批准号:
EP/Y036395/1 - 财政年份:2024
- 资助金额:
$ 11.76万 - 项目类别:
Research Grant
The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopment
IDeA 州临床研究资源中心联盟:通过机会交流、有效营销和劳动力发展增加 IDeA 州的临床试验
- 批准号:
10715568 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
Optimizing integration of veterinary clinical research findings with human health systems to improve strategies for early detection and intervention
优化兽医临床研究结果与人类健康系统的整合,以改进早期检测和干预策略
- 批准号:
10764456 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
The Mayo Clinic NeuroNEXT Clinical Research Site
梅奥诊所 NeuroNEXT 临床研究网站
- 批准号:
10743328 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint
解决临床试验注册表现不佳的问题:开发临床试验工具包并扩大临床研究足迹
- 批准号:
10638813 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
The Minnesota TMD IMPACT Collaborative: Integrating Basic/Clinical Research Efforts and Training to Improve Clinical Care
明尼苏达州 TMD IMPACT 协作:整合基础/临床研究工作和培训以改善临床护理
- 批准号:
10828665 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs
通过与联邦合格的健康中心和社区卫生工作者计划合作,改善临床研究中的多元文化参与
- 批准号:
10823828 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.
在 NCI 资助的临床研究中促进创新、指导、多样性和机会文化:Janice M. Mehnert 医学博士的 NCI 研究专家(临床科学家)奖申请
- 批准号:
10721095 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
Clinical Research Center for REstoration of NEural-based Function in the Real World (RENEW)
现实世界神经功能恢复临床研究中心 (RENEW)
- 批准号:
10795328 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别:
Clinical Research and Academic Success in Obstetrics & Gynecology
产科临床研究和学术成就
- 批准号:
10828252 - 财政年份:2023
- 资助金额:
$ 11.76万 - 项目类别: