Family-Centered Diabetes Project

以家庭为中心的糖尿病项目

• 批准号: 6885740
• 负责人: Carla Jean Herman
• 金额: $ 4.38万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6885740
• 关键词: Native Americans; behavioral /social science research tag; blood tests; body composition; body physical activity; body weight; diabetes education; disease /disorder prevention /control; disease /disorder proneness /risk; education evaluation /planning; family; female; health care service utilization; human subject; insulin sensitivity /resistance; nutrient intake activity; nutrition; nutrition related tag; patient oriented research; physical fitness; questionnaires; role model; women' s health; young adult human (21-34)

Diabetes is a major health problem among Native American (NA) communities nationally and in New Mexico. Diabetes prevention efforts should concentrate on modifiable risk factors. Young NA women are important recipients of diabetes prevention activities because of their pivotal role in the family environment as they purchase and prepare food, and care for their children and families. They are also important recipients of diabetes prevention because of their own high risk of diabetes. Therefore, the long-range goal of this study is to reduce modifiable diabetes risk factors in NA women and their families through a culturally specific intervention. The specific aim of this study is to determine whether a healthful lifestyle intervention program, "Sharing Wisdom", delivered to young NA women without diabetes will reduce diabetes risk factors. A randomized trial design will be used with two experimental groups: intervention group, and comparison group who will receive a delayed intervention. Measures will be completed at the General Clinical Research Center (GCRC) with assistance from the research team at baseline, post intervention, and 6 and 12 months post intervention. Process evaluation will be conducted by a separate team. The target population is NA women ages 18-40 who attend the Indian Health Service (IHS) clinics or an urban Indian clinic. The following hypotheses will be tested: i) Intervention participants will attend the Sharing Wisdom program with a greater than or equal to 80 percent retention rate for the intervention and will evaluate the program positively. ii) Intervention participants will have improvement on diabetes risk factors (primary outcomes) when compared to the comparison group post intervention: decreased percent fat from kcal in the diet, increased vegetable consumption measured using the Block Food Frequency Questionnaire, and increased percent of participants who do moderate or strenuous physical activity for 30 minutes greater than 3 times a week using the Modifiable Activity Questionnaire of Kriska. iii) Intervention participants will improve on clinical measures (secondary outcomes) compared to the comparison group post intervention: improved physical fitness measured by predicted VO2 peak, decreased body fat measured by skinfold thickness, decreased body weight, and decreased insulin resistance using the HOMA model. iv) Improvement in outcome measures will be maintained by intervention participants when compared to the comparison group at 6 and 12 months post intervention.

糖尿病是全国和新墨西哥州美洲原住民(NA)社区的主要健康问题。预防糖尿病的努力应该集中在可改变的危险因素上。青年妇女是糖尿病预防活动的重要接受者，因为她们在购买和准备食物以及照顾子女和家庭方面在家庭环境中发挥着关键作用。他们也是糖尿病预防的重要接受者，因为他们自己患糖尿病的风险很高。因此，这项研究的长期目标是通过文化干预减少NA妇女及其家庭中可改变的糖尿病危险因素。这项研究的具体目的是确定向没有糖尿病的年轻NA妇女提供健康的生活方式干预计划--“分享智慧”--是否会减少糖尿病的危险因素。两个试验组采用随机试验设计：干预组和对照组将接受延迟干预。措施将在综合临床研究中心(GCRC)在研究团队的协助下在基线、干预后以及干预后6个月和12个月完成。流程评估将由一个单独的小组进行。目标人群是在印度卫生服务(IHS)诊所或印度城市诊所就诊的18-40岁的NA妇女。将检验以下假设：i)干预参与者将以大于或等于80%的干预保留率参加分享智慧计划，并将积极评价该计划。Ii)干预后，与对照组相比，干预参与者的糖尿病风险因素(主要结果)将有所改善：饮食中减少了卡路里的脂肪百分比，使用零食频率问卷测量的蔬菜消费量增加，使用Kriska的可修改活动问卷每周进行30分钟中等或剧烈体育活动的参与者的百分比增加了3次。Iii)干预后，与对照组相比，干预参与者的临床指标(次要结果)将有所改善：通过预测的VO2峰值衡量的体能改善，以皮脂厚度衡量的体脂减少，体重减少，以及使用HOMA模型降低胰岛素抵抗。4)在干预后6个月和12个月，与对照组相比，干预参与者将保持结果衡量标准的改善。