Depression Screening & Treatment in Ovarian Cancer

抑郁症筛查

• 批准号: 6947830
• 负责人: EILEEN H SHINN
• 金额: $ 8.48万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947830
• 关键词: behavioral /social science research tag; clinical research; cognitive behavior therapy; depression; diagnosis design /evaluation; female; health care quality; human subject; human therapy evaluation; longitudinal human study; mental disorder diagnosis; ovary neoplasms; patient oriented research; psychological aspect of cancer; telemedicine; training

DESCRIPTION (provided by applicant): Dr. Eileen Shinn earned her Ph.D. in Clinical Psychology from Ohio University and is a postdoctoral fellow in the Department of Behavioral Science at M.D. Anderson Cancer Center. Dr. Shinn will use the K07 award to train with a mentoring team comprised of medical and psychosocial experts at M. D. Anderson and four national experts in depression and primary care research (Drs. James Coyne, Lynn Rehm, John Williams, James Bray). This project has a longitudinal design with an embedded feasibility study to evaluate an innovative intervention for depression. The revised prospective screening plan has been expanded to include a hierarchical screening strategy for depression, as well as additional questions about timing of screening, quality of care received, and basic psychological processes which may affect depression. On the other hand, the pilot intervention has been scaled down and now offers patients a choice of treatment, reflecting the reality of depression treatment in managed-care settings. The training plan now includes formal coursework and workshops suggested by the 4 co-mentors, as well as annual training trips to Dr. James Coyne at U. Penn, and regularly scheduled face-to-face meetings with Drs. Lynn Rehm and James Bray, and to a lesser extent, Dr. John Williams. Formal agreements and specific roles with the mentoring team have been documented and are presented. The research and training plan will be conducted at M.D. Anderson, which has a commitment to research and training with numerous didactic and collaborative opportunities. The Gynecologic Cancer Center at M.D. Anderson treats 250-300 different ovarian cancer patients per year. Major depression is the most prevalent psychiatric disorder in cancer patients and severely disables patients' quality of life. Yet depression is underdiagnosed and inadequately treated when recognized. The research plan proposes to address many of the barriers that hinder the detection and treatment of major depression in busy oncology practice settings. The screening plan now features a brief 2-phase screening method which may demonstrate positive predictive value well above other screening instruments. The pilot intervention will test the feasibility and acceptability among depressed ovarian cancer patients. It will be delivered in the patient's home by telephone and a structured cognitive-behavioral therapy (CBT) journal. The pilot intervention will last 10 sessions over 3 months and cover a range of cognitive-behavioral skills. Each skill will suggest a choice of applications ranging from side-effect management and pain reduction, to concerns about losses in functioning. Drs. Rehm and Taylor will co-supervise Dr. Shinn in the CBT administration. This intervention is innovative and has not been done before with any group of cancer patients, including ovarian cancer patients.

描述（由申请人提供）：Eileen Shinn 博士获得博士学位。 俄亥俄大学临床心理学博士，M.D. 安德森癌症中心行为科学系博士后研究员。 Shinn 博士将利用 K07 奖项与由 M.D. Anderson 的医学和社会心理专家以及四位抑郁症和初级保健研究领域的国家专家（James Coyne、Lynn Rehm、John Williams、James Bray 博士）组成的指导团队进行培训。 该项目采用纵向设计，并嵌入可行性研究，以评估抑郁症的创新干预措施。 修订后的前瞻性筛查计划已扩大到包括抑郁症的分层筛查策略，以及有关筛查时间、接受的护理质量以及可能影响抑郁症的基本心理过程的其他问题。 另一方面，试点干预措施已经缩小，现在为患者提供了一种治疗选择，反映了管理式医疗环境中抑郁症治疗的现实。 现在的培训计划包括 4 位联合导师建议的正式课程和研讨会，以及每年到宾夕法尼亚大学拜访 James Coyne 博士的培训之旅，以及定期安排与 Drs. James Coyne 的面对面会议。林恩·雷姆 (Lynn Rehm) 和詹姆斯·布雷 (James Bray)，以及较小程度上的约翰·威廉姆斯 (John Williams) 博士。 与指导团队的正式协议和具体角色已记录并呈现。 研究和培训计划将在 M.D. Anderson 进行，该机构致力于研究和培训并提供大量教学和合作机会。 M.D. Anderson 的妇科癌症中心每年治疗 250-300 名不同的卵巢癌患者。 重度抑郁症是癌症患者中最常见的精神疾病，严重影响患者的生活质量。 然而，抑郁症在确诊后并未得到充分诊断和治疗。 该研究计划提出解决在繁忙的肿瘤学实践环境中阻碍重度抑郁症检测和治疗的许多障碍。 该筛查计划现在采用简短的两阶段筛查方法，该方法可能显示出远远高于其他筛查工具的阳性预测价值。 试点干预措施将测试抑郁症卵巢癌患者的可行性和可接受性。 它将通过电话和结构化认知行为治疗 (CBT) 日记在患者家中进行。 试点干预将在 3 个月内持续 10 次，涵盖一系列认知行为技能。 每种技能都会建议应用程序的选择，范围从副作用管理和减轻疼痛到对功能丧失的担忧。 博士。 Rehm 和 Taylor 将共同监督 Shinn 博士的 CBT 管理工作。 这种干预措施具有创新性，以前从未在任何癌症患者群体中进行过，包括卵巢癌患者。