MENTAL HEALTH 5 HTIA RECEPTOR AND NEUROPLASTICITY

描述：这是NIMH高级科学家奖(SSA)的申请。在 52岁，有30多年的研究经验，我请求从 非研究职责，以便专注于扩展的研究计划并采取 利用独特和及时的机会在人类身上学习核磁共振。少校 我目前的研究计划的目的是研究基本的细胞和 5-羟色胺介导的啮齿动物神经可塑性的药理学机制 大脑和脊髓。未来五年提出的研究重点是我的 努力扩大我的基础研究目标，并将其扩展到包括 临床研究。在基础研究中，我将研究5-羟色胺参与 与神经再生和细胞凋亡有关。我现在的假设是5-HT1a受体 蛋白质水平和表达与神经元呈负相关 成熟。雅各布斯博士发现5-HT1A受体刺激神经发生 激动剂。Banerjee博士报告说，5-HT1A激动剂激活了MAP-K，它 抑制神经元细胞系中caspase-3的活性和凋亡。我是 定位于进入这些领域并在我目前支持的NIMH基础上进行扩展 将5-HT1a受体与神经可塑性和抑郁症联系起来的研究。我 将扩展我的假设以包括发生在神经发生和 细胞凋亡。第二个主要的职业生涯计划包括获得背景和 在人脑中执行和分析核磁共振成像的经验。Mony DeLeon博士使用 MRI检测内嗅皮层、杏仁核和大脑皮质的形态变化 纽约大学医学中心的海马体。我的长期目标是使用成像技术 对精神病患者群体进行纵向研究的技术 神经整形事件是可疑的。5-羟色胺类药物的治疗策略 将能够直接测试我的基础研究的临床相关性 调查结果。职业发展计划涉及(A)人力资源方面的补充培训 成像技术；(B)探索5-HT1a受体在神经发生中的作用 以及(C)会见该领域的国家和国际专家 神经可塑性作为进一步发展治疗策略的一部分 用药理学逆转精神分裂症患者的神经形态改变 精神错乱。

DESCRIPTION: This is a request for an NIMH Senior Scientist Award (SSA). At the age of 52, with over 30 years of research experience, I request freedom from non-research duties in order to focus on an expanded research program and take advantage of a unique and timely opportunity to learn MRI in humans. The major aim of my present research program is to examine the basic cellular and pharmacological mechanism of serotonin-mediated neuroplasticity in the rodent brain and spinal cord. The research proposed for the next five years focuses my efforts on expanding my basic research objectives and extending them to include clinical research. In basic research, I will study the serotonin involvement with neurogenesis and apoptosis. My current hypothesis is that 5-HT1A receptor protein levels and expression are inversely correlated with neuronal maturation. Dr. Jacobs finds neurogenesis is stimulated by 5-HT1A receptor agonists. Dr. Banerjee reports 5-HT1A agonists activate MAP-kinase, which inhibits caspase-3 activity and apoptosis, in a neuronal cell line. I am positioned to move into these areas and expand on my current NIMH supported research that linked the 5-HT1A receptor to neuroplasticity and depression. I will expand my hypothesis to include events occurring during neurogenesis and apoptosis. The second major career plan involves acquiring the background and experience to perform and analyse MRI in the human brain. Dr. Mony DeLeon uses MRI to detect morphological changes in entorhinal cortex, amygdala and hippocampus at NYU Medical Center. My long-term aims are to use imaging techniques for longitudinal study of a psychiatric patient population where neuroplastic events are suspected. Therapeutic strategies using 5-HT drugs would enable direct testing of the clinical relevance of my basic research findings. Professional growth plans involve (a) supplemental training in human imaging technology; (b) explore the role of the 5-HT1A receptor in neurogenesis and apoptosis and (c) meet with national and international experts in the field of neuroplasticity as part of further development of therapeutic strategies for using pharmacology to reverse neuromorphological changes occurring in mental disorders.