EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT

描述(由申请人提供)： 印第安纳大学医学院(IUSM)通过这项修订后的提案，要求为建造21,000平方米的建筑提供同等资金。英国《金融时报》在IUSM的校园内正在建设的新的研究3大楼的实验室空间非常接近我们学校的其他医学研究大楼。(请参阅附图)。这是一座计划在2007年完工的新楼。这块土地归印第安纳大学董事会所有，这座建筑也将归他们所有。该提案中描述的建设将容纳遗传病和基因转移计划的核心设施，并将使医学院能够继续在遗传和基因治疗研究领域发挥其国家作用。这一建设将使这些项目能够扩大它们目前的努力，包括在普通临床研究中心的DNA储存库服务中发挥更大的作用，扩大IUSM越来越多的涉及生物恐怖主义制剂的研究努力，并促进为新招聘的研究人员创建实验室。这一建设将取代过时的设施，将目前在四座独立建筑的现有实验室工作的研究人员聚集在一起，促进共同的生物信息学和质量保证计划，并为扩大活动提供空间。这一设施将致力于提供跨越医学院几乎每个系的研究基础设施。位于医学和分子遗传学系的DNA和细胞库有着悠久的历史，为当地研究人员的研究提供便利，并为识别与神经疾病相关的基因(包括阿尔茨海默氏症和帕金森氏病)至关重要的样本提供全国资源。位于医学和分子遗传学系内的IU载体生产设施为当地的研究人员提供最先进的基因转移技术，具有载体开发、生产和测试方面的专业知识。该设施精通临床级载体的生产，并已被NCRR指定为国家基因载体实验室(NGVL)。自1995年以来，印第安纳大学还一直担任这一国家计划的协调中心。如下文所述，应NCRR的要求，伊利诺伊大学的NGVL将开始为所有接受学术研究人员赞助的基因治疗的受试者提供存档服务，作为回应FDA关于将所有此类样本保存15年的要求的手段。因此，这项提议现在也涵盖了这项新服务。

DESCRIPTION (provided by applicant): The Indiana University School of Medicine (IUSM) requests, via this revised proposal, matching funding for the construction of 21,000 gross sq. ft. of laboratory space in the new Research 3 Building that is being built on the campus of IUSM in close proximity to the other medical science research buildings at our school. (Please see attached map). This is a new building that is scheduled to be completed by 2007. The land is owned by the Trustees of Indiana University (IU), and the building will be owned by them, too. The construction described in this proposal will house the Core Facilities for the Hereditary Diseases and Gene Transfer Programs and will enable the School of Medicine to continue its national role in the field of genetic and gene therapy research. The construction will permit these programs to expand their current efforts to include an increased role in the General Clinical Research Center for DNA repository services, to expand IUSM's increasing research efforts involving bioterrorism agents, and to facilitate the creation of laboratories for newly recruited research faculty. This construction will replace outdated facilities, bring together researchers currently working in existing laboratories located in four separate buildings, facilitate a common bioinformatics and quality assurance program, and provide space for expanded activities. This facility will be dedicated to supplying research infrastructure that spans almost every department in the School of Medicine. The DNA and Cell Repository located within the Department of Medical and Molecular Genetics has a long-standing history of facilitating the research of local investigators as well as providing a national resource for samples critical in the identification of genes associated with neurological disorders, including Alzheimer and Parkinson's diseases. The IU Vector Production Facility, housed within the Department of Medical and Molecular Genetics, provides state-of-the-art gene transfer technology to investigators locally, with expertise in vector development, production, and testing. The facility is well versed in the production of clinical grade vectors and has been designated by the NCRR as a National Gene Vector Laboratory (NGVL). IU also has served as the Coordinating Center for this national program since 1995. As noted below, at the request of NCRR, the NGVL at IU will begin to provide archiving services for all subjects undergoing gene therapy treatments sponsored by academic investigators, as a means of responding to FDA's requirements for saving all such samples for 15 years. Thus, this proposal now encompasses this new service as well.