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EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT

校外研究设施的改善

基本信息

批准号：
6828036
负责人：
Rose S Fife
金额：
$ 367.86万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6828036
关键词：
biomedical facility building /facility design /renovation medical education molecular genetics

项目摘要

DESCRIPTION (provided by applicant): The Indiana University School of Medicine (IUSM) requests, via this revised proposal, matching funding for the construction of 21,000 gross sq. ft. of laboratory space in the new Research 3 Building that is being built on the campus of IUSM in close proximity to the other medical science research buildings at our school. (Please see attached map). This is a new building that is scheduled to be completed by 2007. The land is owned by the Trustees of Indiana University (IU), and the building will be owned by them, too. The construction described in this proposal will house the Core Facilities for the Hereditary Diseases and Gene Transfer Programs and will enable the School of Medicine to continue its national role in the field of genetic and gene therapy research. The construction will permit these programs to expand their current efforts to include an increased role in the General Clinical Research Center for DNA repository services, to expand IUSM's increasing research efforts involving bioterrorism agents, and to facilitate the creation of laboratories for newly recruited research faculty. This construction will replace outdated facilities, bring together researchers currently working in existing laboratories located in four separate buildings, facilitate a common bioinformatics and quality assurance program, and provide space for expanded activities. This facility will be dedicated to supplying research infrastructure that spans almost every department in the School of Medicine. The DNA and Cell Repository located within the Department of Medical and Molecular Genetics has a long-standing history of facilitating the research of local investigators as well as providing a national resource for samples critical in the identification of genes associated with neurological disorders, including Alzheimer and Parkinson's diseases. The IU Vector Production Facility, housed within the Department of Medical and Molecular Genetics, provides state-of-the-art gene transfer technology to investigators locally, with expertise in vector development, production, and testing. The facility is well versed in the production of clinical grade vectors and has been designated by the NCRR as a National Gene Vector Laboratory (NGVL). IU also has served as the Coordinating Center for this national program since 1995. As noted below, at the request of NCRR, the NGVL at IU will begin to provide archiving services for all subjects undergoing gene therapy treatments sponsored by academic investigators, as a means of responding to FDA's requirements for saving all such samples for 15 years. Thus, this proposal now encompasses this new service as well.

描述（由申请人提供）：印第安纳州大学医学院（IUSM）通过这一修订后的提案，要求为21,000平方米的建筑提供配套资金。英尺在新的研究3楼的实验室空间，这是正在建设的IUSM校园在靠近我们学校的其他医学科学研究大楼。（请参阅附图）。这是一座新建筑，计划于2007年完工。这块土地归印第安纳州大学（IU）的受托人所有，这座建筑也将归他们所有。本提案中描述的建设将容纳遗传性疾病和基因转移计划的核心设施，并将使医学院继续在遗传和基因治疗研究领域发挥其国家作用。建设将允许这些方案扩大其目前的努力，包括在一般临床研究中心的DNA储存库服务中发挥更大的作用，扩大IUSM日益增加的涉及生物恐怖主义制剂的研究工作，并促进为新招募的研究人员创建实验室。该建筑将取代过时的设施，将目前在四个独立建筑物中的现有实验室工作的研究人员聚集在一起，促进共同的生物信息学和质量保证计划，并为扩大活动提供空间。该设施将致力于提供跨越医学院几乎每个部门的研究基础设施。位于医学和分子遗传学系内的DNA和细胞储存库长期以来一直致力于促进当地研究人员的研究，并为识别与神经系统疾病（包括阿尔茨海默病和帕金森病）相关的基因至关重要的样本提供国家资源。疾病。IU载体生产设施位于医学和分子遗传学系内，为当地研究人员提供最先进的基因转移技术，并具有载体开发，生产和测试方面的专业知识。该设施精通临床级载体的生产，并已被NCRR指定为国家基因载体实验室（NGVL）。自1995年以来，IU还担任这一国家方案的协调中心。如下文所述，应NCRR的要求，IU的NGVL将开始为接受学术研究者申办的基因治疗的所有受试者提供存档服务，以响应FDA关于将所有此类样本保存15年的要求。因此，这项建议现在也包括这项新的服务。

项目成果

期刊论文数量（21）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Performance of candidate urinary biomarkers for pancreatic cancer - Correlation with pancreatic cyst malignant progression?

胰腺癌候选尿液生物标志物的性能 - 与胰腺囊肿恶性进展的相关性？

DOI：
10.1016/j.amjsurg.2019.09.013
发表时间：
2020
期刊：
American journal of surgery
影响因子：
3
作者：
Yip-Schneider,MicheleT;Soufi,Mazhar;Carr,RosalieA;Flick,KatelynF;Wu,Huangbing;Colgate,CameronL;Schmidt,CMax
通讯作者：
Schmidt,CMax

AMPD1 polymorphism and response to regadenoson.

AMPD1 多态性和对 regadenoson 的反应。

DOI：
10.2217/pgs.15.116
发表时间：
2015
期刊：
Pharmacogenomics
影响因子：
2.1
作者：
Saab,Rayan;Zouk,AlineN;Mastouri,Ronald;Skaar,ToddC;Philips,Santosh;Kreutz,RolfP
通讯作者：
Kreutz,RolfP

Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer.