How chronic stress and depression harm the heart

慢性压力和抑郁如何损害心脏

• 批准号: nhmrc : 569299
• 负责人: A/Pr Eugene Nalivaiko
• 金额: $ 24.81万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chronic-stress-depression-harm-heart/94482
• 关键词: How; chronic; stress; depression; harm

Very little is known about mechanisms whereby depression harms the heart. This is especially disturbing as recent evidence indicates that while antidepressants alleviate a depressed persons negative mood, they do not eliminate danger to the heart. We will use an animal model to determine: How depression affects the electrical stability of the heart; The identity of the brain mechanisms that are involved; and which drugs can be used to protect the heart fro the harmful effects of depression.

人们对抑郁症损害心脏的机制知之甚少。这是特别令人不安的，因为最近的证据表明，虽然抗抑郁药减轻了抑郁症患者的负面情绪，但它们并没有消除对心脏的危险。我们将使用动物模型来确定：抑郁症如何影响心脏的电稳定性;所涉及的大脑机制的身份;以及哪些药物可以用来保护心脏免受抑郁症的有害影响。