CORE--ANIMAL PROCEDURES

核心——动物程序

• 批准号: 7100664
• 负责人: Bernard E. Weissman
• 金额: $ 6.28万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7100664
• 关键词: animal colony; biomedical facility; carcinogen testing; chemical synthesis; disease /disorder model; drug screening /evaluation; laboratory mouse; neoplasm /cancer; reagent /indicator; veterinary science

The goal of the Animal Procedures Core Facility is to provide a central facility staffed by two skilled individuals to promote reproducible experimentation in laboratory animals. Services include drug screening, tumorigenicity testing and reagent production and small animal colony management. The Core is led by Dr. Bernard Weissman and Ms. Natalie Edmunds. The Core adds value to the Center by providing the animal tumor model expertise lacking in most laboratories, reducing the overall cost of such studies, ensuring a high level of reproducibility for animal studies and fostering interactions between Cancer Center members. Highlights of research supported by the Core include: highly-skilled maneuvers to characterize novel antineoplastic reagents including: intra-tibial inoculations, oral garage, and new treatments of NPC tumors with adenoviral reagents. Future plans for the Core include the addition of new Cancer Center users, expansion of colony management services including genotyping in conjunction with the Animal Models Core Facility and integration of small animal imaging with the new Small Animal Imaging Core Facility.

动物程序核心设施的目标是提供一个由两名熟练人员组成的中心设施，以促进实验室动物的可重复实验。服务包括药物筛查、致瘤性检测、试剂生产和小动物群体管理。核心由伯纳德·韦斯曼博士和娜塔莉·埃德蒙兹女士领导。核心通过提供大多数实验室缺乏的动物肿瘤模型专业知识，降低此类研究的总体成本，确保动物研究的高水平再现性，并促进癌症中心成员之间的互动，为中心增加了价值。核心支持的研究重点包括： 试剂，包括：胫骨内接种，口服车库，和新的治疗NPC肿瘤， 腺病毒试剂。 核心的未来计划包括增加新的癌症中心用户，扩大菌落管理服务，包括与动物模型核心设施一起进行基因分型，以及将小动物成像与新的小动物成像核心设施整合。