Animal Models Core Facility

动物模型核心设施

• 批准号: 8340285
• 负责人: Bernard E. Weissman
• 金额: $ 29.15万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-23 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340285
• 关键词: Academia; Alleles; Animal Model; Animals; Antineoplastic Agents; Area; Basic Science; Biological Models; Biotechnology; Budgets; Cancer Center; Carcinogenicity Tests; Cells; Complex; Comprehensive Cancer Center; Core Facility; Development; Engineering; Faculty; Funding; Gap Junctions; Gene Targeting; Genetic Medicine; Genetic screening method; Genetically Engineered Mouse; Grant; Growth; Home environment; Homologous Gene; Human; Human Resources; Image; Immunocompetent; Individual; Institutes; International; Investments; Knock-out; Laboratory Animals; Leadership; Malignant Neoplasms; Modeling; Molecular Biology; Mus; Nature; Nobel Prize; Oncogene Proteins; Peer Review; Pharmacodynamics; Phase; Phenotype; Physiological; Positioning Attribute; Prevention; Production; Protocols documentation; Quality Control; Reagent; Recording of previous events; Reproducibility; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Screening procedure; Specificity; Strategic Planning; System; Technology; Testing; Therapeutic; Therapy Clinical Trials; Toxicology; Training; Transgenic Model; Transgenic Organisms; Translational Research; UNC Lineberger Comprehensive Cancer Center; United States National Institutes of Health; Viral; Work; Xenograft procedure; animal model development; anticancer research; cancer genetics; cost; design; good laboratory practice; host neoplasm interaction; improved; member; mouse model; novel; novel therapeutics; pre-clinical; programs; skills; tool; tumor; tumor xenograft

Animal Models Core Facility We are combining two previous cores dealing with mouse cancer nnodels into a single Animal IVIodeis Core that functions to help LCCC members with all aspects of mouse-related research. Core staff assists with animal handling, xenograft tumor models, colony management, therapeutic trials, imaging studies, allele phenotyping and the design and production of genetically engineered mice (GEM). This core adds value to the Cancer Center by enabling cost-efficient murine testing even by members who do not have significant infrastructure and expertise for animal work. The core is co-directed by Chariene Ross and Dale Cowley, with faculty co-advisors Norman Sharpless and Bernard Weissman. Dr. Sharpless and Dr. Cowley have been added to the leadership since the last cycle to add expertise in GEM models and expand core capabilities. Experimental help spans the spectrum from transgenic / knockout allele production and design to allele phenotyping, animal imaging and therapeutic testing of novel anti-cancer agents in xenograft and genetically engineered tumor models. The core has 39 users (97% use by peer reviewed members for Animal Studies). Significant growth has occurred in the animal studies component of the core during the last year with core staff operating beyond overall capacity since August 2009. We request an increased budget of $283,591 that will represent 15% of the total Animal Models Core budget to promote expanded use. The Animal Models Core will grow significantly during the next cycle, driven largely by increased NIH funding to UNC investigators, the 50% increase in campus animal space and a strategic plan featuring cancer genetics and preclinical therapeutics testing. The Genetic Medicine building has recently opened with space for over 40,000 additional cages. The Imaging Research Building will open in 2013 with 2,000 additional cages for longitudinal mouse therapy and Imaging protocols. The Animal Models Core is well positioned to become the nexus for Cancer Center members exploiting the power of GEMs and xenograft tumor models for basic and translational cancer research.

动物模型核心机构 我们正在将之前两个处理小鼠癌症nodels的核心合并为一个动物IVIodeis核心，其功能是帮助LCCC成员进行小鼠相关研究的各个方面。核心工作人员协助动物处理，异种移植肿瘤模型，集落管理，治疗试验，成像研究，等位基因表型和基因工程小鼠（GEM）的设计和生产。这一核心增加了 癌症中心通过使具有成本效益的小鼠测试，即使是成员谁不具有重要的基础设施和专业知识的动物工作。核心是共同指导的夏琳罗斯和戴尔考利，与教师共同顾问诺曼夏普勒斯和伯纳德韦斯曼。自上一个周期以来，Sharpless博士和Cowley博士已加入领导层，以增加GEM模型方面的专业知识并扩大核心能力。实验帮助涵盖了从转基因/敲除等位基因生产和设计到等位基因表型分析、动物成像和异种移植和基因工程肿瘤模型中新型抗癌药物的治疗测试的范围。核心有39个用户（97%的使用者是动物研究的同行评审成员）。去年，核心的动物研究部分出现了显著增长，自2009年8月以来，核心工作人员的工作超出了总体能力。我们要求增加预算 283，591美元，占动物模型核心预算总额的15%，以促进扩大使用。 动物模型核心将在下一个周期显着增长，主要是由于NIH增加了对癌症研究人员的资助，校园动物空间增加了50%，以及一项以癌症遗传学和临床前治疗测试为特色的战略计划。遗传医学大楼最近开放了超过40，000个额外的笼子。影像研究大楼将于2013年开放， 用于纵向小鼠治疗和成像方案的笼。动物模型核心有能力成为癌症中心成员的纽带，利用GEM和异种移植肿瘤模型的力量进行基础和转化癌症研究。