Feasibility of Rehabilitation Robots and fMRI in Stroke

康复机器人和功能磁共振成像在中风中的可行性

• 批准号: 6970070
• 负责人: A ARIA TZIKA
• 金额: $ 24万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6970070
• 关键词: biofeedback; bioimaging /biomedical imaging; body movement; clinical research; functional magnetic resonance imaging; human subject; human therapy evaluation; magnetism; medical rehabilitation related tag; patient oriented research; quality of life; rehabilitation; robotics; stroke; stroke therapy

DESCRIPTION (provided by applicant): Broad long-term objectives: To improve the rehabilitation and quality of life of stroke patients. Hypothesis: Optimally designed Magnetic Resonance (MR) compatible robotic devices can assist in movement rehabilitation of stroke-induced pathological or traumatic changes by stimulating plasticity of primary motor cortex representations and cell properties. Specific Aims: (1) To build novel MR compatible rehabilitation force-feedback robotic devices and tested them in healthy volunteers using an optimal functional MR imaging (fMRI) protocol: and (2) demonstrate the relevance of combining these robotic devices and fMRI for evaluating rehabilitation in stoke patients. Health relatedness: An increasing number of patients suffer from stroke, a major cause of invalidity in modern society. Monitoring and validating the effectiveness of stroke rehabilitation therapy is challenging, since its physiological requirements include both peripheral and central nervous system plasticity. State-of-the-art functional MR methods combined with novel MR compatible robotic rehabilitation devices, which are developed and tested in this proposal, can provide accurate, sensitive and specific information about the effectiveness of rehabilitation therapy beyond traditional approaches. Research design and methods: This exploratory study will generate pilot data for the feasibility of monitoring rehabilitation maneuvers in stroke patients with a state-of-the-art MR system using novel IvR compatible robotic devices. Stroke patient appropriate tasks suitable for our MR compatible robots will be designed, tested and optimized with an MR system that uses phased-array coils, to increase sensitivity and resolution. fMRI will be performed on 6 healthy adult volunteers and 6 stroke patients; and methods will be optimized to measure activation in voluntary movement-related cortical areas. Project rationale and significance: By demonstrating the utility of fMRI to monitor the effectiveness of rehabilitation maneuvers in stroke patients, these studies can ultimately provide an additional method for the future evaluation of stroke rehabilitation therapies. To this end, the anticipated results may lead to the development of a novel optimized method for stroke patient rehabilitation; and upon further development this method could become a valuable tool to illuminate stroke-induced pathological and traumatic changes, and to provide unique prospective information for stroke patient management.

描述（由申请人提供）：广泛的长期目标：改善中风患者的康复和生活质量。 假设：优化设计的磁共振（MR）兼容机器人设备可以通过刺激初级运动皮层表征和细胞特性的可塑性来辅助中风引起的病理或创伤性变化的运动康复。具体目标：（1）构建新型MR兼容康复力反馈机器人设备，并使用最佳功能性MR成像（fMRI）协议在健康志愿者中对其进行测试;（2）证明将这些机器人设备与fMRI结合用于评估斯托克患者康复的相关性。 健康相关性：越来越多的患者患有中风，这是现代社会残疾的主要原因。监测和验证中风康复治疗的有效性是具有挑战性的，因为其生理要求包括外周和中枢神经系统的可塑性。国家的最先进的功能MR方法结合新的MR兼容的机器人康复设备，这是开发和测试的建议，可以提供准确，灵敏和具体的信息，康复治疗的有效性超出传统的方法。 研究设计和方法：本探索性研究将生成试点数据，用于使用最先进的MR系统（使用新型IvR兼容机器人器械）监测卒中患者的康复操作的可行性。中风患者适当的任务适合我们的MR兼容机器人将设计，测试和优化与MR系统，使用相控阵线圈，以提高灵敏度和分辨率。将对6名健康成年志愿者和6名中风患者进行功能磁共振成像，并优化方法以测量自主运动相关皮质区的激活。 项目原理和意义：通过证明功能磁共振成像监测中风患者康复策略的有效性，这些研究最终可以为未来评估中风康复治疗提供额外的方法。为此，预期的结果可能会导致开发一种新的优化方法，中风患者的康复，并在进一步发展这种方法可能成为一个有价值的工具，照亮中风引起的病理和创伤性变化，并提供独特的前瞻性信息中风患者的管理。