The development of synthetic cells using industry 4.0 technologies

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Chemical biology and the field of synthetic cell science offer the potential to construct biomimetic entities from non-living components, rationally combined to create tailorable structural elements and functional pathways. These constructs, often taking the form of 'artificial cells', are designed to sustain complex life-like responses, including metabolism, communication, decision making, motility, and even evolution, and promise to revolutionise fundamental and applied science. This studentship will look at the development of a new generation of synthetic cells with the capability for targetted delivery and synthesis at the site of action. Coupled with innovation in the physical sciences their design and construction will be driven through integration with industry 4.0 platforms such as additive manufacturing, artificial intelligence (AI) and machine learning (ML), leading to digitisation of the design-test cycles. This will facilitate the high-throughput sweeping of parameters such as membrane chassis composition which in turn regulate synthetic cell stability, the rate of signal propagation via bio-circuitry and cell-environment communication. Coupling 3D microfluidic printing with robotics and automation with transform the field of synthetic cell construction.