Synthetic Strategies for Photosensitive Organic Diagnostics

光敏有机诊断的合成策略

• 批准号: 2600909
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2600909
• 关键词: Synthetic; Strategies; Photosensitive; Organic; Diagnostics

Molecular recognition plays an essential role in all biological processes: from the molecular machinery of the ribosome that translates RNA into proteins, to the antibody-antigen response that has been at the centre of efforts to produce a Covid-19 vaccine. Many of these biological interactions occur over large surface areas that have evolved over vast periods of time to optimise both affinity and specificity. Can the power and creativity of organic synthesis be harnessed to produce small molecules that match the exquisite recognition properties of large biologics? This project will develop structure-guided rationally designed synthetic receptors of therapeutically relevant targets, with a particular focus on peptide- and protein-surface recognition in oncology and amyloidogenic degenerative conditions. The synthetic receptors will be displayed on a thin-film polymeric support integrated with a mid-IR photonic device. The resulting thin-film sensor will be tuned to recognise low concentrations of biochemical analyte in body fluids such as saliva and blood plasma. The long-term aim is application in clinical settings for point-of-care biochemical analysis.

分子识别在所有生物过程中都发挥着至关重要的作用：从将RNA转化为蛋白质的核糖体的分子机制，到一直是生产Covid-19疫苗工作核心的抗体-抗原反应。许多这些生物相互作用发生在大的表面区域，经过长时间的进化，以优化亲和性和特异性。有机合成的力量和创造力能否被用来制造出与大型生物制剂的精细识别特性相匹配的小分子？该项目将开发结构导向的合理设计的合成受体，用于治疗相关靶点，特别关注肿瘤和淀粉样变性疾病中的肽和蛋白质表面识别。合成受体将显示在集成了中红外光子器件的薄膜聚合物载体上。由此产生的薄膜传感器将被调整为识别体液（如唾液和血浆）中低浓度的生化分析物。长期目标是应用于临床设置点护理生化分析。