MEMS-Enabled Ventricular Catheter for Hydrocephalus

用于治疗脑积水的 MEMS 心室导管

• 批准号: 6938324
• 负责人: SELENE A LEE
• 金额: $ 2.92万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-31 至 2009-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6938324
• 关键词: biomaterial development /preparation; biomaterial interface interaction; biomechanics; catheterization; cell adhesion; cerebral ventricles; cerebrospinal fluid pressure; hydrocephalus; implant; medical implant science; predoctoral investigator

DESCRIPTION (provided by applicant): One of the most common treatments for patients with hydrocephalus is the surgical implantation of a cerebrospinal-fluid (CSF) shunt. Unfortunately, this device, which is critical for managing hydrocephalus, has a substantial failure rate. The goal of this project is to reduce the frequency of catheter replacement surgeries or to eliminate them all together. I propose to accomplish this by designing a ventricular catheter that will resist occlusion due to cellular accumulation, through the use of micromachining and biological micro-electro-mechanical systems (bioMEMS) technologies. Magnetic microactuators, produced with MEMS technologies, have been operated in biological fluids without the need for a directly wired power supply or control electronics. Such a microactuator technology could be used to mitigate catheter obstruction in a permanently implanted device. The specific aims are: (1) to design, fabricate, and use an in vitro test setup to analyze the obstruction process, (2) to design and implement a magnetic microactuator can be used to resist obstruction, (3) to use the in vitro setup to analyze the obstruction and the obstruction-clearing1 process for the prototype design.

描述(申请人提供)：脑积水患者最常见的治疗方法之一是手术植入脑脊液分流术。不幸的是，这种对治疗脑积水至关重要的设备有相当高的故障率。该项目的目标是减少导管更换手术的频率或将其全部消除。我建议通过使用微机械和生物微电子机械系统(BioMEMS)技术来设计一种能够抵抗细胞堆积导致的闭塞的脑室导管来实现这一点。利用MEMS技术生产的磁性微执行器已经在生物液体中运行，不需要直接连接的电源或控制电子设备。这种微致动器技术可以用来减轻永久植入装置中的导管阻塞。具体目标是：(1)设计、制造并使用体外测试装置来分析阻塞过程；(2)设计并实现可用于抵抗阻塞的磁性微执行器；(3)使用体外装置来分析阻塞以及用于原型设计的清除阻塞过程。