Molecular Regulation of CD8 T Cell Memory by BCL-6

BCL-6 对 CD8 T 细胞记忆的分子调节

• 批准号: 6895483
• 负责人: ERIC T CLAMBEY
• 金额: $ 4.99万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6895483
• 关键词: cell differentiation; cytotoxic T lymphocyte; gene induction /repression; genetically modified animals; immunologic memory; laboratory mouse; postdoctoral investigator; protein structure function; transcription factor

DESCRIPTION (provided by applicant): Following exposure to antigen, host lymphocytes go through a process of differentiation resulting in the generation of antigen-specific memory lymphocytes. Memory T cells provide a pool of antigen-specific lymphocytes capable of rapid response following antigen re-exposure. While T cell memory is beginning to be understood at the cellular level, the transcriptional regulation involved in memory is poorly understood. Recent genetic data have identified bcl-6, a sequence-specific transcriptional repressor, as a regulator of CD8 T cell memory. This proposal will focus on the role of bcl-6 in the generation of CD8 memory T cells, by defining the kinetics and function of bcl-6 in memory CD8 T cell development and survival. These studies will provide insight into the molecular regulation of CD8 T cell memory. Furthermore, they may identify specific methods to accentuate CD8 T cell memory to aid in clearance of infection, or to prevent inappropriate development of autoreactive CD8 memory T cells.

描述（由申请人提供）：暴露于抗原后，宿主淋巴细胞经历分化过程，导致抗原特异性记忆淋巴细胞的产生。记忆 T 细胞提供了一组抗原特异性淋巴细胞，能够在抗原再次暴露后快速做出反应。虽然人们开始在细胞水平上了解 T 细胞记忆，但对记忆中涉及的转录调控却知之甚少。最近的遗传数据已确定 bcl-6（一种序列特异性转录抑制因子）可以作为 CD8 T 细胞记忆的调节因子。该提案将通过定义 bcl-6 在记忆 CD8 T 细胞发育和存活中的动力学和功能，重点关注 bcl-6 在 CD8 记忆 T 细胞生成中的作用。这些研究将深入了解 CD8 T 细胞记忆的分子调节。此外，他们可能会确定增强 CD8 T 细胞记忆的具体方法，以帮助清除感染，或防止自身反应性 CD8 记忆 T 细胞的不当发育。