Race & Viral Resistance in Chronic Hepatitis C (VIRAHEP*
种族
基本信息
- 批准号:6896117
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-01 至 2006-04-30
- 项目状态:已结题
- 来源:
- 关键词:African Americancaucasian Americanchronic disease /disorderclinical trialscombination chemotherapyfibrosisgenotypehepatitis Chepatitis C virushuman subjecthuman therapy evaluationimmunogeneticsinterferonsliver disordermicroorganism disease chemotherapyobesitypathologic processpatient oriented researchquality of liferacial /ethnic differenceribavirinsocioeconomicstherapy complianceurban areavirulencevirus genetics
项目摘要
DESCRIPTION (provided by applicant):
The pathogenesis of hepatitis C (HCV) associated liver injury is poorly
understood. Studies of HCV pathogenesis have been impeded by the lack of an
animal model, the inability to maintain HCV in cell culture systems, and the
slow progression of disease, which hinders natural history studies. However,
though host and viral factors likely play a role in liver injury, neither has
been rigorously analyzed. Early studies suggest that viral clearance with acute
infection as well as with treatment is markedly decreased iin patients of
African American heritage. The reasons for this poor response are not
understood, but possibly relate to differences in demographics (e.g
socioeconomic status), comorbid conditions (e.g., obesity), genotype
distribution or virulence, viral kinetics, immune response, and compliance with
therapy. Previous studies have been limited by small sample size and referral
bias. Over the last 2 years, The Columbia-Cornell Liver Clinical Trials Network
has established an extended network of care that has performed clinical trials
including a large number of African Americans. This Network includes the
Columbia Presbyterian and Harlem Hospital Centers both within the Harlem
section of Manhattan and The New York-Cornell Center in central Manhattan.
Within this ethnically diverse population, we will answer several questions.
The primary hypothesis is that treatment response to PEGylated interferon and
ribavirin is decreased in African Americans. However, we postulate that most of
this decrease can be explained by differences in baseline characteristics and
non-biologic parameters, including body mass index, comorbid medical
conditions, socioeconomic status and the ability to complete therapy.
Additionally we will search for clinical predictors of response to therapy
including differences in immunogenetics and early viral kinetics. The secondary
hypothesis is that the progression of liver disease in African Americans is
comparable to that in a Caucasian American population after controlling for
potential confounders including the variables mentioned above and alcohol
consumption.
描述(由申请人提供):
丙型肝炎相关肝损伤的发病机制尚不清楚
明白了。丙型肝炎病毒致病机制的研究因缺乏
动物模型,在细胞培养系统中维持丙型肝炎病毒的能力,以及
疾病进展缓慢,这阻碍了自然历史研究。然而,
尽管宿主和病毒因素可能在肝脏损伤中发挥作用,但两者都没有。
经过了严格的分析。早期研究表明,病毒清除与急性
感染以及接受治疗的患者显著减少
非裔美国人的传统。这种反应不佳的原因并不是
理解,但可能与人口统计差异有关(例如
社会经济地位)、共病情况(如肥胖)、基因
分布或毒力、病毒动力学、免疫反应和依从性
心理治疗。以前的研究受到样本量小和转介的限制
偏见。在过去的两年里,哥伦比亚-康奈尔大学肝脏临床试验网络
已经建立了一个扩展的护理网络,已经进行了临床试验
包括大量的非裔美国人。该网络包括
哥伦比亚长老会和哈莱姆医院中心都在哈莱姆区
曼哈顿的一部分和曼哈顿中心的纽约-康奈尔中心。
在这个种族多元化的人群中,我们将回答几个问题。
主要假设是对聚乙二醇化干扰素和
利巴韦林在非裔美国人中减少。然而,我们假设,大多数
这一下降可以用基线特征和
非生物参数,包括体重指数,共病医学
条件、社会经济地位和完成治疗的能力。
此外,我们还将寻找治疗反应的临床预测指标。
包括免疫遗传学和早期病毒动力学的差异。第二个
假设非裔美国人肝病的进展是
与高加索美国人在控制了
潜在的混杂因素,包括上述变量和酒精
消费。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT S BROWN其他文献
ROBERT S BROWN的其他文献
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{{ truncateString('ROBERT S BROWN', 18)}}的其他基金
Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network
肝硬化结果预防的策略和治疗:STOP-C 肝硬化网络
- 批准号:
10492742 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network
肝硬化结果预防的策略和治疗:STOP-C 肝硬化网络
- 批准号:
10311423 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network
肝硬化结果预防的策略和治疗:STOP-C 肝硬化网络
- 批准号:
10700170 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network
肝硬化结果预防的策略和治疗:STOP-C 肝硬化网络
- 批准号:
10690121 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
PEB IFN AND RIBAVIRIN VERSUS REBETRON IN HEPATITIS C
PEB IFN 和利巴韦林与 ReBETRON 治疗丙型肝炎的对比
- 批准号:
6567820 - 财政年份:2001
- 资助金额:
$ 10万 - 项目类别:
ADEFOVIR DIPIVOXIL FOR PATIENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION
阿德福韦酯用于慢性乙型肝炎病毒感染患者
- 批准号:
6567828 - 财政年份:2001
- 资助金额:
$ 10万 - 项目类别: