Sustainable Access to Chiral Organophosphorus Compounds

可持续获取手性有机磷化合物

• 批准号: 2601727
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2601727
• 关键词: Sustainable; Access; Chiral; Organophosphorus; Compounds

Project background (identification of the problem and its importance and relevance to sustainability) Phosphorus atoms are found in a variety drugs, agrochemicals and catalysts that are vital to our every-day lives. These atoms often occupy specific geometries which can be challenging to synthesise selectively. In recent years, scrutiny has been placed not only on the commercial viability of the processes which produce these chemicals, but also on their environmental impact. Unfortunately, phosphorus chemistry is quite problematic in this respect: most phosphorus compounds ultimately come from phosphate rock, which is first converted into white phosphorus in a very energy intensive process, and then into more advanced building blocks. A major phosphorus-based building blocks used in the chemical industry is phosphorus trichloride. This compound is made via the direct combination of white phosphorus and chlorine gas (both of which are chemical weapons). Reliance on PCl3 as a starting material is an undesirable state of affairs owing to the compound's toxicity and status as a chemical weapons precursor. Relieving our dependence on this problematic reagent would be highly desirable and is what this project seeks to achieve. This will involve developing new synthetic methods as well as improving pre-existing ones. Proposed solution and methodology Our proposed solution is to use stable precursors based on higher oxidation states of phosphorus. We will develop catalytic methods based on naturally-available molecules to control the geometry at phosphorus as new groups are introduced, and the complexity of the building block is increased.

项目背景（识别问题及其对可持续发展的重要性和相关性）磷原子存在于对我们日常生活至关重要的各种药物、农用化学品和催化剂中。这些原子通常占据特定的几何形状，选择性合成可能具有挑战性。近年来，不仅对生产这些化学品的工艺的商业可行性进行了审查，而且还对其环境影响进行了审查。不幸的是，磷化学在这方面存在相当大的问题：大多数磷化合物最终来自磷酸盐岩，磷酸盐岩首先在非常耗能的过程中转化为白色磷，然后转化为更先进的建筑材料。 在化学工业中使用的主要的磷基结构单元是磷酸盐。这种化合物是由白色磷和氯气（两者都是化学武器）直接结合而成。依赖PCl 3作为起始材料是不可取的，因为该化合物具有毒性，而且是化学武器前体。减轻我们对这种有问题的试剂的依赖是非常可取的，也是该项目寻求实现的目标。这将涉及开发新的合成方法以及改进现有的方法。 提出的解决方案和方法我们提出的解决方案是使用基于较高氧化态磷的稳定前体。我们将开发基于天然分子的催化方法，以控制磷的几何形状，因为引入了新的基团，并且结构单元的复杂性增加了。