A New Technique for Central Visual Field Analysis

中央视野分析新技术

• 批准号: 6925952
• 负责人: LEI LIU
• 金额: $ 12.68万
• 依托单位: LIGHTHOUSE INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6925952
• 关键词: clinical research; computer human interaction; diagnosis design /evaluation; diagnosis quality /standard; eye disorder diagnosis; eye fundus photography; human subject; psychophysics; scotoma; stimulus /response; technology /technique development; vision tests; visual fields; visual perception; visual stimulus; visual tracking

DESCRIPTION (provided by applicant): Quick, accurate and affordable assessment of visual field defects (scotomas) provides crucial information for the purposes of diagnosing eye diseases, selecting appropriate medical interventions, monitoring the effectiveness of therapeutic procedures, and predicting rehabilitation needs. Automated perimetry is time-consuming and unsuitable for frequent monitoring of rapid development of diseases such as age-related macular degeneration (AMD). It becomes unreliable when steady central fixation cannot be maintained. The Amsler grid test has been shown to be insensitive and unreliable. The goal of the proposed research is to evaluate the efficacy of a new visual field test for assessing the central visual field. In this Regular Dot-Array Test (RDAT) a rectilinear dot-array is flashed briefly, and a scotoma manifests itself as an interruption of the regular dot pattern, typically, some missing dots. The patient describes the immediate percept of the interruption by reporting the number of abnormal dots. The following characteristics distinguish the RDAT from existing visual field tests: 1) It uses spatially extended regular dot-arrays to examine a large area of the visual field simultaneously. 2) The regularity of a dot-array allows subjects to make quantitative reports about the sizes of perceived field defects instantly, and thus the test result doesn't depend critically on the subject's ability to maintain steady fixation. 3) The dot-array density can be adjusted to reduce perceptual filling-in (PFI) so that small and long-standing scotomas can be detected. 4) It is possible to account for the effect of dot-array PFI, so that the sizes of scotomas can be more accurately determined. 5) The test can be conducted on personal computers, and thus is widely accessible. The combination of these characteristics makes the RDAT an important addition to existing field tests. It can be useful in situations where existing field tests have been shown to be ineffective or unreliable (central scotomas associated with AMD, for example), or where a quick and low-cost assessment of visual field is desired (screening, primary care settings, or self-administered monitoring). 5 specific aims will be accomplished. 1) Determine the optimal testing parameters and procedure for the RDAT. 2) Assess the sensitivity and specificity of the RDAT for detecting macular scotomas. 3) Assess the ability of the RDAT to quantify the sizes and locations of scotomas. 4) Assess the test/retest reliability, the dependence on fixation stability and the efficiency of the RDAT, in relation to existing visual field tests. 5) Establish the relationship between the findings of the RDAT and existing field tests. The long-term goal is to develop a low-cost, easy-to-use, and widely accessible clinical tool for evaluating the macula.

描述（由申请人提供）：快速、准确和负担得起的视野缺陷（暗点）评估为诊断眼病、选择适当的医疗干预、监测治疗程序的有效性和预测康复需求提供了关键信息。自动眼周检查耗时且不适合频繁监测诸如年龄相关性黄斑变性（AMD）等疾病的快速发展。当稳定的中心固定不能维持时，它就变得不可靠了。阿姆斯勒网格试验已被证明是不敏感和不可靠的。本研究的目的是评估一种评估中央视野的新视野测试的有效性。在这个规则点阵列测试（RDAT）中，一个直线点阵列被短暂地闪过，暗点表现为规则点模式的中断，通常是一些缺失的点。患者通过报告异常点的数量来描述对中断的直接感知。RDAT与现有的视野测试有以下特点：1)使用空间扩展的规则点阵列同时检查大面积的视野。2)点阵的规律性使被试能够即时定量报告感知到的场缺陷的大小，因此测试结果并不严重依赖于被试保持稳定注视的能力。3)可以调整点阵密度，减少感知填充（PFI），从而检测到小而长期存在的暗点。4)可以考虑点阵PFI的影响，从而可以更准确地确定暗点的大小。5)测试可以在个人电脑上进行，因此可以广泛使用。这些特性的结合使RDAT成为现有现场测试的重要补充。在现有的现场测试已被证明无效或不可靠的情况下（例如，与AMD相关的中心暗点），或在需要对视野进行快速和低成本评估的情况下（筛查、初级保健设置或自我管理监测），它可能是有用的。5个具体目标将会实现。1)确定RDAT的最佳测试参数和程序。2)评估RDAT检测黄斑暗斑的敏感性和特异性。3)评估RDAT量化暗点大小和位置的能力。4)相对于现有的视野测试，评估测试/重测试的可靠性、对注视稳定性的依赖性和RDAT的效率。5)建立RDAT结果与现有现场试验之间的关系。长期目标是开发一种低成本，易于使用和广泛使用的临床工具来评估黄斑。