Development and Validation of a Holographic Waveguide-based Oculometer for Objective and Comprehensive Oculomotor Disorder Assessment

基于全息波导的眼科计的开发和验证，用于客观和全面的动眼障碍评估

• 批准号: 9360550
• 负责人: LEI LIU
• 金额: $ 18.93万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9360550
• 关键词: Affect; Anterior; Asthenopia; Back; Caring; Clinic; Clinical; Clinical Management; Clinical Research; Cornea; Coupled; Data; Detection; Development; Devices; Diagnosis; Disease; Evaluation; Eye; Eye Movements; Film; Glass; Goals; Head; Health; Human; Imaging technology; Individual; Instruction; Intervention; Judgment; Learning; Life; Light; Lighting; Location; Measurement; Measures; Methodology; Modality; Modeling; Monitor; Movement; Optics; Outcomes Research; Patients; Performance; Performance at work; Pupil; Quality of life; Reading; Regimen; Reporting; Research; Research Personnel; Resolution; Retina; Retinal; Rotation; Saccades; Side; Signal Transduction; Strabismus; Symptoms; System; Technology; Testing; Thinness; Time; Triad Acrylic Resin; Validation; Visible Radiation; Visual; Visual Accommodation; Work; Writing; base; compliance behavior; design; experience; human subject; improved; instrument; lens; light weight; luminance; novel; oculomotor; pediatric patients; prototype; relating to nervous system; research and development; research clinical testing; response; sample fixation; sensor; skills

Summary: The goal of this research is to test the feasibility of applying the existing Holographic Waveguide (HW) technology to conduct comprehensive and objective clinical evaluation of binocular eye movement, accommodation and pupil size (oculomotor components). In humans, these components are intricately coupled to form coherent visual routines for viewing targets at different directions and distances (the triad). Abnormalities in oculomotor components and in their interactions are a highly prevalent health issue, often associated with visual symptoms and difficulties completing educational and work-related tasks. Current clinical oculomotor assessments typically evaluate individual oculomotor components in isolation and usually rely on the patient's subjective report and on clinician's subjective judgment. The difficulties caused by the lack of devices that can perform objective, simultaneous assessment of all oculomotor responses have long been recognized by clinicians and researchers alike. HW technology may serve as the platform for such a device. In a HW, light signal is coupled into a glass substrate at an angle satisfying the requirement of total internal reflection via a thin-film holographic in-coupler pasted at one location on the substrate, propagates in the substrate and is coupled out from the substrate at a different location via a matching out-coupler. It provides a highly compact and lightweight light signal pipeline--a piece of glass in front of the eye--that can conduct illumination light to the eye and also capture light reflected back from the eye. The purpose of the proposed research is to test the feasibility of using a HW-based oculometer to perform objective measurement all oculomotor components. To achieve this goal, two specific aims will be pursued. First, a desktop prototype of a HW-based oculometer will be developed. Near infrared light will be waveguided to a location in front of the eye to provide co-axial illumination. Reflections from the cornea, the pupil and the retina will be captured in front of the eye and will be waveguided to a camera and a wave-front sensor to extract eye movement and accommodation data. Second, the accuracy and precision of the prototype will be evaluated first with model eyes and then with young normal human subjects. The human subject evaluations will include fixation, saccade, vergence and accommodation recordings with the prototype. These recordings will be compared with recordings obtained with commercially available eye tracker and autorefractor. It is our goal to reach a 0.1o or better precision over a range of 15o of visual angles for eye movement and a 0.35 diopters or better precision over a range of 12 diopters for accommodation. If HW is proven a viable platform for oculomotor assessment, a HW-based, wearable, see-through clinical device will be developed that can assess all oculomotor responses objectively and simultaneously over longer period of time while the patient is engaged in normal visual activities, such as reading and writing at a desk. Not only will it improve the quality and efficiency of current oculomotor disorder care but will also improve diagnosis of intermittent, task-related, or emergent disorders.

摘要：本研究的目的是测试应用现有全息光波导的可行性。 (HW)技术对双眼运动进行全面和客观的临床评估， 调节和瞳孔大小(动眼部分)。在人类身上，这些成分错综复杂地耦合在一起 形成连贯的视觉程序，用于观察不同方向和距离的目标(三合一)。 动眼神经成分及其相互作用的异常是一个非常普遍的健康问题，通常 与视觉症状和完成教育和工作相关任务的困难有关。当前 临床眼球运动评估通常孤立地评估单个眼球运动成分，通常 依靠患者的主观报告和临床医生的主观判断。由于缺乏而造成的困难 长期以来，能够对所有眼球运动反应进行客观、同时评估的设备 得到了临床医生和研究人员的一致认可。硬件技术可以作为这种设备的平台。在……里面 HW光信号以满足整体内部要求的角度耦合到玻璃基板上 通过粘贴在衬底上的一个位置的薄膜全息内耦合器的反射在 并且通过匹配的外耦合器从不同位置处的基板耦合出来。它提供了一个 高度紧凑和轻便的光信号管道--一块放在眼睛前面的玻璃--可以传导 照明光到眼睛，也捕捉从眼睛反射回来的光。建议的目的是 研究旨在测试使用基于硬件的视力计进行客观测量的可行性 动眼神经组件。为了实现这一目标，将追求两个具体目标。首先，一个桌面原型 将开发基于硬件的视力计。近红外光将被引导到眼睛前面的位置 以提供同轴照明。角膜、瞳孔和视网膜的反射将被捕捉到 并将被引导到摄像机和波前传感器以提取眼睛运动和 住宿数据。其次，首先用模型对样机的精度和精度进行评估 然后是年轻的正常人类受试者。人类受试者的评估将包括注视， 与原型的扫视、融合和住宿记录。这些录音将与 用市售的眼球跟踪器和自动验光仪获得的记录。我们的目标是达到0.1%或 在15度视角范围内获得更高的眼动精度和0.35屈光度或更高的精度 在12个屈光度范围内提供住宿。如果HW被证明是一个可行的眼球运动评估平台， 将开发一种基于硬件的、可穿戴的透明临床设备，可以评估所有的眼动反应 在患者处于正常视力的较长时间内客观且同时进行 活动，如在办公桌前阅读和写作。它不仅将提高电流的质量和效率 眼球运动障碍的护理，但也将提高间歇性，任务相关，或紧急疾病的诊断。