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MWCE: Transmission/Pathogenesis of Bioterrorism Agents

MWCE：生物恐怖主义制剂的传播/发病机制

基本信息

批准号：
6797820
负责人：
Patrick M Schlievert
金额：
$ 67.1万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-04 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6797820
关键词：
Bacillus anthracis bioterrorism /chemical warfare clinical research tularemia vaccine evaluation

项目摘要

DESCRIPTION (provided by applicant): This P-RCE brings together the strengths of 77 researchers, both basic and clinical and from both Universities and Industry, in the states of Minnesota, Illinois, Michigan, Indiana, and Ohio. Administrative infrastructure for this application includes leadership at each one of the institutions involved. Our research strengths are in Basic Biology of Category A agents of Bioterrorism, Inhalation Biology and Host Response to Category A organisms, Diagnostics and Experimental Therapeutics, and Vaccine Evaluation, the latter where we have two premier organizations committed to participate. We are particularly interested in moving basic research into clinical application. We submit two R01s and several concept projects in these areas. The first R01 seeks funding to study a novel two-component regulatory system in Bacillus anthracis that in other Gram-positive bacteria is essential to virulence. We have shown that the regulatory system homologue exists in B. anthracis and have initiated studies to clone and insertionally inactivate the system. Furthermore, we hypothesize that this regulatory system is the target of compounds that we have identified and inhibit production of exotoxins. The second R01 provides an example of our strength in Inhalation Biology with a project to study the mechanism underlying Francisella tularensis entry and trafficking into macrophages, and the role surfactant plays in these processes. Concept projects complement these studies and initiate research into Category A viral agents. We anticipate that in 1-2 years these grants will develop into 3-4 program projects. In addition, we have assembled a team of highly-skilled leaders to train both present and future researchers in the safe handling of Category A agents; we have a large collective number of BSL3 facilities to achieve this training, combined with a well-conceived plan. Finally, we have begun development of seamless interactions with first-line emergency responders in all Region V states, with our intent to serve as overflow "Bench Workers" if bioterrorism events occur.

描述（由申请人提供）：本P-RCE汇集了来自明尼苏达州、伊利诺伊州、密歇根州、印第安纳州和俄亥俄州的77名基础和临床研究人员的力量。这一应用的行政基础设施包括所涉每个机构的领导。我们的研究优势是生物恐怖主义，吸入生物学和宿主对A类生物体的反应，诊断和实验治疗学以及疫苗评估的A类制剂的基础生物学，后者我们有两个主要组织致力于参与。我们对将基础研究转化为临床应用特别感兴趣。我们在这些领域提交了两个R 01和几个概念项目。第一个R 01寻求资金来研究炭疽芽孢杆菌中一种新的双组分调控系统，该系统在其他革兰氏阳性细菌中对毒力至关重要。我们已经证明了调控系统同源物存在于B中。炭疽菌，并已开始研究克隆和插入测序系统。此外，我们假设，这种调节系统是我们已经确定的化合物的目标，并抑制外毒素的产生。第二个R 01提供了我们在吸入生物学方面的优势的一个例子，该项目研究了土拉热弗朗西斯菌进入和贩运到巨噬细胞的机制，以及表面活性剂在这些过程中的作用。概念项目补充了这些研究，并启动了对A类病毒因子的研究。我们预计，在1-2年内，这些赠款将发展成为3-4个项目。此外，我们还组建了一个高技能的领导团队，培训现在和未来的研究人员安全处理A类药物;我们有大量的BSL 3设施来实现这一培训，并结合精心策划的计划。最后，我们已经开始与第五区所有州的一线应急人员建立无缝互动，我们打算在发生生物恐怖主义事件时充当额外的“替补工作人员”。