权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

MWCE: Transmission/Pathogenesis of Bioterrorism Agents

MWCE：生物恐怖主义制剂的传播/发病机制

基本信息

批准号：
6797820
负责人：
Patrick M Schlievert
金额：
$ 67.1万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-04 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6797820
关键词：
Bacillus anthracis bioterrorism /chemical warfare clinical research tularemia vaccine evaluation

项目摘要

DESCRIPTION (provided by applicant): This P-RCE brings together the strengths of 77 researchers, both basic and clinical and from both Universities and Industry, in the states of Minnesota, Illinois, Michigan, Indiana, and Ohio. Administrative infrastructure for this application includes leadership at each one of the institutions involved. Our research strengths are in Basic Biology of Category A agents of Bioterrorism, Inhalation Biology and Host Response to Category A organisms, Diagnostics and Experimental Therapeutics, and Vaccine Evaluation, the latter where we have two premier organizations committed to participate. We are particularly interested in moving basic research into clinical application. We submit two R01s and several concept projects in these areas. The first R01 seeks funding to study a novel two-component regulatory system in Bacillus anthracis that in other Gram-positive bacteria is essential to virulence. We have shown that the regulatory system homologue exists in B. anthracis and have initiated studies to clone and insertionally inactivate the system. Furthermore, we hypothesize that this regulatory system is the target of compounds that we have identified and inhibit production of exotoxins. The second R01 provides an example of our strength in Inhalation Biology with a project to study the mechanism underlying Francisella tularensis entry and trafficking into macrophages, and the role surfactant plays in these processes. Concept projects complement these studies and initiate research into Category A viral agents. We anticipate that in 1-2 years these grants will develop into 3-4 program projects. In addition, we have assembled a team of highly-skilled leaders to train both present and future researchers in the safe handling of Category A agents; we have a large collective number of BSL3 facilities to achieve this training, combined with a well-conceived plan. Finally, we have begun development of seamless interactions with first-line emergency responders in all Region V states, with our intent to serve as overflow "Bench Workers" if bioterrorism events occur.

描述（由申请人提供）：这个P-RCE汇集了来自明尼苏达州、伊利诺伊州、密歇根州、印第安纳州和俄亥俄州的77名研究人员的优势，包括基础和临床，以及来自大学和工业界的研究人员。此应用程序的管理基础设施包括所涉及的每个机构的领导。我们的研究优势是生物恐怖主义A类制剂的基础生物学，吸入生物学和对A类生物的宿主反应，诊断和实验治疗，以及疫苗评估，我们有两个主要组织承诺参与后者。我们对将基础研究转化为临床应用特别感兴趣。我们在这些领域提交了两个r01和几个概念项目。第一个R01寻求资金来研究一种在其他革兰氏阳性细菌中对毒力至关重要的炭疽芽孢杆菌中新的双组分调控系统。我们已经证明调控系统同源物存在于炭疽芽孢杆菌中，并已经开始克隆和插入灭活该系统的研究。此外，我们假设这个调节系统是我们已经确定并抑制外毒素产生的化合物的目标。第二个R01提供了我们在吸入生物学方面的优势的一个例子，该项目研究土拉菌进入和运输巨噬细胞的机制，以及表面活性剂在这些过程中所起的作用。概念项目补充了这些研究，并启动了对A类病毒制剂的研究。我们预计在1-2年内，这些资助将发展成3-4个项目。此外，我们已经组建了一支高技能的领导团队，培训现在和未来的研究人员安全处理a类药剂；我们有大量的BSL3设施来实现这种培训，并结合了一个精心设计的计划。最后，我们已经开始与所有第五区州的一线应急人员建立无缝互动，我们打算在发生生物恐怖主义事件时充当溢出的“替补工作人员”。