Training in Mechanisms of Parasitism

寄生虫机制培训计划一直是该大学的一个持续计划 连续19年都在爱荷华州。该计划联合了研究不同微生物系统的科学家 和方法，但解决类似的问题“寄生”，即微生物的发病机制， 疾病因此，该学院为学员提供了解决基本问题的机会 关于微生物致病机理的研究。我们的基本假设是 原生动物、蠕虫、细菌和病毒病原体在克服这些障碍时面临着类似的障碍， 哺乳动物的抗微生物防御一种病原体逃避杀戮的机制 在宿主体内的研究可以提供对其他病原体以其独特的方式生存的见解。 宿主生态位有一个长期的历史，合作研究和培训的实验室之间， 爱荷华州的大学，特别是这个寄生虫计划的成员之间。有了这个新 我们已经扩大了我们的视野，以满足日益增长的协作专业知识的需求， 基因组、转录组、蛋白质组、微生物组和噬菌体组， 从大量的数据集和方法/模型来解决这些假设。 这个跨部门，跨学科的计划利用教师在四个 在爱荷华州的大学的部门和四个跨学科的项目。我们的活动旨在 激励和加强不仅培养我们的学生和博士后学者，而且在 加强具有不同专业领域的教职员工之间的协作互动。在 特别是，我们已经增加了在生物信息学和流行病学的专业知识教师的教师名单。 我们目前的教师已经在微生物毒力机制方面有相当深入的研究 和宿主的先天性和适应性免疫反应。我们的目标是采用，默认情况下，让我们的学员 对宿主、微生物和 这是导致寄生的环境。我们以前的学员都非常成功; 100%的 那些完成培训的人在生物医学科学或相关领域担任职务， 54%的人拥有大学终身职位，39%的人在工业领域从事研究。在这 我们建议采用更佳的方法，协助学员发展事业。我们有 成功地招募了少数族裔候选人，并提出进一步加强这一点的办法。 总的来说，我们认为这是一个全面的计划，以培养学生和博士后学者， 寄生虫的各个方面，并为他们在生物医学研究中的生产性职业做好准备。

The Mechanisms of Parasitism training program has been an ongoing program at the University of Iowa for 19 sequential years. The program unites scientists working on different microbial systems and methods, but addressing similar questions about “Parasitism”, i.e. the pathogenesis of microbial diseases. Thus this faculty provides trainees with an opportunity to address basic questions regarding microbial pathogenesis using a full repertoire of techniques. Our underlying hypothesis is that protozoal, helminthic, bacterial, and viral pathogens face similar obstacles in overcoming mammalian antimicrobial defenses. The mechanisms through which one pathogen evades killing within the host may provide insights into means through which other pathogens survive in their unique host niche. There is a long history of collaborative research and training among the laboratories at the University of Iowa, and particularly between members of this Parasitism program. With this new application we have expanded our horizons to meet the growing need for collaborative expertise in genomes, transcriptomes, proteomes, microbiomes and phageomes, drawing on logical hypotheses from massive data sets and methods/ models to address these hypotheses. This interdepartmental, interdisciplinary program draws upon faculty members in four departments and four interdisciplinary programs at the University of Iowa. Our activities are aimed at inspiring and enhancing not only training of our students and postdoctoral scholars, but also at enhancing the collaborative interactions between faculty members with different areas of expertise. In particular we have added faculty with expertise in Bioinformatics and Epidemiology to the faculty list. Our current faculty members already have considerable depth in mechanisms of microbial virulence and host innate and adaptive immune responses. We aim to adopt, and by default, have our trainees adopt a more comprehensive view of the intricate relationships between host, microbe and environment that contributed to parasitism. Our prior trainees have been highly successful; 100% of those who are done with training have assumed positions in the biomedical sciences or related fields, with 54% holding tenure track university positions and 39% performing research in industry. In this application we propose an enhanced approach to helping trainees develop their careers. We have been successful at recruiting minority candidates and propose means to enhance that even further. Overall we view this as a comprehensive program to train students and postdoctoral scholars in diverse aspects of parasitism, and to prepare them for productive careers in biomedical research.