Training in Mechanisms of Parasitism

寄生机制培训

• 批准号: 9151124
• 负责人: Patrick M Schlievert
• 金额: $ 27.39万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9151124
• 关键词: Training; parasitism

The Mechanisms of Parasitism training program has been an ongoing program at the University of Iowa for 19 sequential years. The program unites scientists working on different microbial systems and methods, but addressing similar questions about “Parasitism”, i.e. the pathogenesis of microbial diseases. Thus this faculty provides trainees with an opportunity to address basic questions regarding microbial pathogenesis using a full repertoire of techniques. Our underlying hypothesis is that protozoal, helminthic, bacterial, and viral pathogens face similar obstacles in overcoming mammalian antimicrobial defenses. The mechanisms through which one pathogen evades killing within the host may provide insights into means through which other pathogens survive in their unique host niche. There is a long history of collaborative research and training among the laboratories at the University of Iowa, and particularly between members of this Parasitism program. With this new application we have expanded our horizons to meet the growing need for collaborative expertise in genomes, transcriptomes, proteomes, microbiomes and phageomes, drawing on logical hypotheses from massive data sets and methods/ models to address these hypotheses. This interdepartmental, interdisciplinary program draws upon faculty members in four departments and four interdisciplinary programs at the University of Iowa. Our activities are aimed at inspiring and enhancing not only training of our students and postdoctoral scholars, but also at enhancing the collaborative interactions between faculty members with different areas of expertise. In particular we have added faculty with expertise in Bioinformatics and Epidemiology to the faculty list. Our current faculty members already have considerable depth in mechanisms of microbial virulence and host innate and adaptive immune responses. We aim to adopt, and by default, have our trainees adopt a more comprehensive view of the intricate relationships between host, microbe and environment that contributed to parasitism. Our prior trainees have been highly successful; 100% of those who are done with training have assumed positions in the biomedical sciences or related fields, with 54% holding tenure track university positions and 39% performing research in industry. In this application we propose an enhanced approach to helping trainees develop their careers. We have been successful at recruiting minority candidates and propose means to enhance that even further. Overall we view this as a comprehensive program to train students and postdoctoral scholars in diverse aspects of parasitism, and to prepare them for productive careers in biomedical research.

寄生虫机制培训计划一直是该大学正在进行的计划 在爱荷华州连续19年。该计划将致力于不同微生物系统的科学家团结在一起 和方法，但解决类似的问题的“寄生”，即微生物的发病机制 疾病。因此，该教员为学员提供了解决基本问题的机会 关于微生物的致病机理，使用了一整套技术。我们的基本假设是 原生动物、蠕虫、细菌和病毒病原体在克服这些障碍方面面临着相似的障碍 哺乳动物的抗微生物防御系统。一种病原体逃避杀戮的机制 可以提供对其他病原体在其独特的 东道主利基。实验室之间的合作研究和培训有很长的历史， 爱荷华大学，特别是这个寄生计划的成员之间。有了这个新的 应用程序我们已经扩展了我们的视野，以满足不断增长的协作专业知识需求 基于逻辑假设的基因组、转录组、蛋白质组、微生物组和噬菌体 从海量数据集和方法/模型中找到解决这些假设的方法。 这个跨部门、跨学科的项目吸引了四名教职员工。 爱荷华大学的多个系和四个跨学科项目。我们的活动旨在 不仅激励和加强我们的学生和博士后学者的培训，而且在 加强不同专业领域的教职员工之间的协作互动。在……里面 特别是，我们增加了在生物信息学和流行病学方面具有专业知识的教师名单。 我们目前的教职员工已经对微生物毒力的机制有了相当深入的了解。 以及宿主先天和获得性免疫反应。我们的目标是领养，默认情况下，我们的实习生 更全面地看待寄主、微生物和 导致寄生的环境。我们之前的学员非常成功；100% 那些接受过培训的人已经在生物医学科学或相关领域担任过职务， 54%的人在大学担任终身教职，39%的人从事工业研究。在这 我们提出了一种改进的方法来帮助实习生发展他们的职业生涯。我们有 在招聘少数族裔候选人方面取得了成功，并提出了进一步加强这一点的方法。 总体而言，我们认为这是一个全面的项目，旨在培训学生和博士后学者 帮助他们了解寄生虫的不同方面，并为他们在生物医学研究中从事富有成效的职业做好准备。