ORWH: SCOR--Sex /Gender Factors Affecting Women's Health

ORWH:SCOR——影响女性健康的性别因素

基本信息

  • 批准号:
    7026829
  • 负责人:
  • 金额:
    $ 3.52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-09-30 至 2007-08-31
  • 项目状态:
    已结题

项目摘要

On a global basis, urinary tract infections (UTIs), which are among the most common infectious diseases in the United States, occur -150 million times annually and account for more than $6 billion in direct health care costs. UTIs primarily affect women because of the female- anatomy and the ascending nature of the disease. The Gram-negative bacterium Escherichia coli is the most common cause of these infections which account for significant morbidity. In addition, to the original infection one of the major clinical problems is recurrence. A woman treated for an uncomplicated UTI has a 25-50% chance of developing a recurrent infection. It has generally been assumed that UTIs are caused by non-invasive bacteria, that they are acute in nature, and are self-limited. It has also been assumed that recurrent infections are due to re-inoculation of the urinary tract with E.coli from an intestinal or vaginal reservoir. Recent evidence suggests that this dogma may in some cases be incorrect and misleading and could be interfering with the proper evaluation and treatment of these infections. This proposal seeks to elucidate the molecular and epidemiologic basis of acute and recurrent UTIs. Special emphasis will be placed on better defining the epidemiology of UTIs, determining the presence of persistent bacterial bladder and vaginal reservoirs following acute symptomatic UTI in women and elucidating the molecular factors involved in the host-pathogen interaction. The temporal, associations between asymptornatic and symptomatic bladder infection and vaginal colonization in the clinical setting will be assessed. Molecular characterization of the virulence determinants in well-characterized uropathogenic strains will be elucidated by blending a powerful genetic system with functional genomics, defined in vitro and murine models, biochemistry, cell biology, and high resolution electron microscopy. The mechanistic details of how the bladder responds to infection, and how specific virulence. factors affect this host response will be determined using microarray, quantitative RT-PCR and laser capture microdis section. This proposal represents an intricate and integrated network between three projects and will lead to a new understanding of the host-pathogen interactions that occur throughout the infectious cycle including the host defense response in the bladder and the virulence mechanisms by which bacterial pathogens subvert these defenses. Results of this research could revolutionize the way UTIs are evaluated and lead to new and better ways to treat and prevent this infection that primarily affects women.
在全球范围内,尿路感染(UTI)是美国最常见的传染病之一,每年发生约1.5亿次,直接医疗保健费用超过60亿美元。UTI主要影响女性,因为女性解剖学和疾病的提升性质。革兰氏阴性细菌大肠杆菌是这些感染的最常见原因,其导致显著的发病率。此外,原发感染的主要临床问题之一是复发。一个女人治疗一个简单的UTI有25-50%的机会发展为复发性感染。一般认为UTI是由非侵入性细菌引起的,它们本质上是急性的,并且是自限性的。也有人认为,复发性感染是由于从肠道或阴道贮库再次接种大肠杆菌所致。最近的证据表明,这种教条在某些情况下可能是不正确的和误导性的,可能会干扰这些感染的正确评估和治疗。该建议旨在阐明急性和复发性尿路感染的分子和流行病学基础。将特别强调更好地定义UTI的流行病学,确定存在持续性细菌膀胱和阴道水库后,急性症状性UTI的妇女和阐明参与宿主-病原体相互作用的分子因素。将评估临床环境中无症状和症状性膀胱感染与阴道定植之间的时间相关性。将阐明一个强大的遗传系统与功能基因组学,定义在体外和小鼠模型,生物化学,细胞生物学和高分辨率电子显微镜的毒力决定因素的分子特征。膀胱如何对感染作出反应的机制细节,以及具体毒力如何。影响这种宿主反应的因素将使用微阵列、定量RT-PCR和激光捕获显微切片来确定。该提案代表了三个项目之间的复杂和综合网络,并将导致对整个感染周期中发生的宿主-病原体相互作用的新理解,包括膀胱中的宿主防御反应和细菌病原体破坏这些防御的毒力机制。这项研究的结果可能会彻底改变UTI的评估方式,并导致新的更好的方法来治疗和预防这种主要影响女性的感染。

项目成果

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SCOTT J. HULTGREN其他文献

SCOTT J. HULTGREN的其他文献

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{{ truncateString('SCOTT J. HULTGREN', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10162824
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Innovative Strategies to Combat Antibiotic-resistant Infections
对抗抗生素耐药性感染的创新策略
  • 批准号:
    10162823
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Innovative Strategies to Combat Antibiotic-resistant Infections
对抗抗生素耐药性感染的创新策略
  • 批准号:
    10352464
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Innovative Strategies to Combat Antibiotic-resistant Infections
对抗抗生素耐药性感染的创新策略
  • 批准号:
    10577797
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10577798
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Development of anti-adhesin mAbs and high-affinity ligand mimetics to treat and prevent UTIs
开发抗粘附素单克隆抗体和高亲和力配体模拟物来治疗和预防尿路感染
  • 批准号:
    10162827
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10352465
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Development of anti-adhesin mAbs and high-affinity ligand mimetics to treat and prevent UTIs
开发抗粘附素单克隆抗体和高亲和力配体模拟物来治疗和预防尿路感染
  • 批准号:
    10577806
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
Development of anti-adhesin mAbs and high-affinity ligand mimetics to treat and prevent UTIs
开发抗粘附素单克隆抗体和高亲和力配体模拟物来治疗和预防尿路感染
  • 批准号:
    10352469
  • 财政年份:
    2021
  • 资助金额:
    $ 3.52万
  • 项目类别:
SMALL MOLECULE BACTERIAL LECTIN ANTAGONISTS FOR UTI TREATMENT AND PREVENTION
用于治疗和预防尿路感染的小分子细菌凝集素拮抗剂
  • 批准号:
    9234333
  • 财政年份:
    2017
  • 资助金额:
    $ 3.52万
  • 项目类别:
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