Administrative Core

行政核心

基本信息

批准号：
10352465
负责人：
SCOTT J. HULTGREN
金额：
$ 36.09万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10352465
关键词：
Affinity Antibiotic Resistance Antibiotics Area Attention Bacteria Bacterial Adhesins Bacterial Antibiotic Resistance Bacterial Infections Basic Science Budgets COVID-19 Cellular biology Centers for Disease Control and Prevention (U.S.)Clinical Collaborations Combating Antibiotic Resistant Bacteria Communication Communication Methods Development Doctor of Philosophy Electronic Mail Ensure Fostering Funding Goals Grant Guidelines Health Human Immunology Infection Institution Interdisciplinary Study International Journals Leadership Ligands Medicine Membrane Methodology Microbiology Monitor Monoclonal Antibodies Multi-Drug Resistance Nosocomial Infections Pathogenicity Peer Review Persons Pharmaceutical Chemistry Physiology Program Evaluation Progress Reports Publications Regulation Research Research Personnel Research Project Grants Resource Sharing Schedule Scientist Series Site Visit Teleconferences Therapeutic Translating Translations United States United States National Institutes of Health Wages antibiotic resistant infections combat data exchange improved functioning individual responsibility innovation meetings member mimetics novel antibiotic class pathogen pathogenic bacteria prevent product development programs rational design response small molecule inhibitor success therapeutic development

项目摘要

PROJECT SUMMARY/ ABSTRACT: COVID-19 exemplifies the dire consequences of being unprepared for the next health crisis. One looming crisis involves the insidious rise of antibiotic resistant bacterial infections, necessitating the research described in our U19 application entitled “Innovative strategies to combat antibiotic-resistant infections” in response to RFA-AI-20-001 (Combating Antibiotic-resistant Bacteria Interdisciplinary Research Units (CARBIRU)). Our proposal is leveraged to translate basic science into new types of antibiotic-sparing medicines for common infections in the United States as well as common hospital-acquired infections. This U19 application utilizes a multi-departmental, multi-institutional, and interdisciplinary group of highly motivated microbiology, cell biology/physiology, immunology and medicinal chemistry researchers to develop antibiotic-sparing therapeutics and compounds that are capable of: i) treating common infections; and/or ii) increasing sensitivity to the current arsenal of available antibiotics. The Administrative Core (AC) will be responsible for coordinating the activities and monitoring the progress of the three research projects and the two scientific cores to achieve the overall goals of the U19 program. To accomplish this, the AC Leader, with the help of an Executive Committee comprising of the Leaders of the Research Projects and Cores, will oversee and coordinate the activities of the members of the Projects and Cores by: i) fostering frequent interactions; ii) supporting the exchange of data, methodologies, and ideas; iii) facilitating interactions with institutional and outside experts to gain advice for better functioning of the overall program and for translation of the program's findings into therapeutics development; and iv) coordinating financial and scientific progress reporting to granting agency staff. In addition, the AC will coordinate active participation in the U19 to ensure its overall success.

项目摘要/摘要： Covid-19表明了对下一次健康危机的严重后果。一个损失危机涉及抗生素耐药细菌感染的阴险崛起，这是进行我们所描述的研究所必需的 U19申请名为“对抗抗生素抗生素感染的创新策略”，以应对 RFA-AI-20-001（对抗抗抗生素的细菌跨学科研究单位（Carbiru））。我们的建议将基础科学转化为常见的新型抗生素药物美国的感染以及常见的医院获得感染。此U19应用程序使用了多部门，多机构和跨学科的小组生物学/生理学，免疫学和药物化学研究人员开发抗生素比较能够：i）治疗常见感染的治疗和化合物；和/或ii）提高灵敏度到当前可用抗生素的武器库。行政核心（AC）将负责协调活动和监视三个研究项目和两个科学核心的进度 U19计划的总体目标。为此，在执行官的帮助下，AC负责人委员会完成研究项目和核心的领导者，将监督和协调项目和核心成员的活动通过：i）促进经常互动； ii）支持交换数据，方法和想法； iii）支持与机构和外部专家的互动获得更好地发挥整体程序的建议，并将程序的调查结果转化为治疗发展； iv）协调向赠款机构的财务和科学进步报告职员。此外，AC将协调U19的积极参与，以确保其整体成功。