Ventilator-Associated Pneumonia. Bactericidal Trachea

呼吸机相关肺炎。

• 批准号: 6966902
• 负责人: THEODOR KOLOBOW
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6966902
• 关键词: biomedical equipment development; bronchial mucus; clinical biomedical equipment; clinical research; human subject; human therapy evaluation; intubation; nonhuman therapy evaluation; nosocomial infection control; nosocomial infections; patient oriented research; pneumonia; respirators; respiratory therapy; sheep; trachea

1. We have previously developed a method to totally clean the lumen of the tracheal tube in intubated sheep thorough the use of a catheter tip mounted inflatable balloon, provided with two "Shaving Rings"; upon inflation and retrieval of the Mucus Shaver, all mucus within the tracheal tube is removed in one sweep. 2. Now undergoing late stage test/evaluation is a novel system that, when implemented, is capable to maintain the tracheal tube, and the trachea free of mucus, and free of bacterial colonization; with no need for tracheal, or tracheal tube suctioning. 3. Based on above studies, and our preceeding studies, a clinical study is to be conducted headed by a former Visiting Fellow (Dr. Lorenzo Berra), in collaboration with PCCM, to evaluate clinical benefits of 1.The mucus shaver and 2. Tracheal tubes coated with silver sulfadiazine in polyhurethane. Such clinical protocol has been approved by the IRB of the participating hospital administration in Italy, and by the NHLBI IRB. The patient population is to consist of both patients in the medical ICU; and cardiosurgical patients

1.我们已经开发了一种方法，通过使用导管尖端安装的充气气囊，配备两个“剃须环”，完全清洁插管绵羊的气管管腔；当充气和回收粘液剃须刀时，一次扫除气管内的所有粘液。 2.目前正在进行后期测试/评估的是一种新的系统，在实施时，它能够保持气管和气管没有粘液，没有细菌定植；不需要气管或气管导管吸引。 3.在上述研究和我们之前的研究的基础上，将与PCCM合作进行一项临床研究，由前访问研究员Lorenzo Berra博士领导，以评估1.粘液剃须刀和2.在聚氯乙烯中涂有磺胺嘧啶银涂层的气管导管的临床益处。这样的临床方案已经得到了意大利参与医院管理的IRB和NHLBI IRB的批准。患者群体将包括内科ICU患者和心脏外科患者。