Nosocomial Pneumonia. Bacteriacidal Tracheal Tubes

院内肺炎。

基本信息

项目摘要

We have further elucidated factors that prevent nosocomial pneumonia in patients intubated, and on mechanical ventilation (MV), using the sheep model. 1. CASS (continuous aspiration of subglottic secretions), now widely practiced clinically, was shown to be of no benefit, and was associated with significant tracheal mucosal injury. 2. A brief 24 h of MV, with head positioned as now clinically practiced, followed by extubation was associated (and in the absence of any adverse clinical findings) with high probability of significant bacterial colonization of the lungs, bursts of bacteremia, and high incidence of nosocomial pneumonia during the subsequent 2 days. 3. When sheep were intubated with tracheal tubes coated with silver sulfadiazine and chlorhexidine, and mechanically ventilated for 24 h, there was no bacterial growth in the tracheal tube, in the water trap, or in the inspiratory and expiratory lines of the mechanical ventilator. This preliminary finding is the first report of absence of bacterial growth in the ventilator circuit after 24 h of MV. 4. Combined with our earlier findings showing absence of bacterial growth in the trachea, and in the lungs, when the trachea and the tracheal tube were oriented below horizontal, our findings suggest preventive measures during mechanical ventilation that can be of importance in determining the presence/absence of bacterial colonization of the ventilator system, and of the upper and lower respiratory tracts.
我们已经进一步阐明了因素,防止医院内肺炎的病人插管,机械通气(MV),使用绵羊模型。 1.卡斯(声门下分泌物连续抽吸),现在广泛应用于临床,被证明是没有好处的,并与显着的气管粘膜损伤。 2.按照目前临床实践的头部定位进行短暂的24 h MV,随后拔管(并且在没有任何不良临床发现的情况下)与随后2天内肺部显著细菌定植、菌血症爆发和院内肺炎的高发生率相关。 3.当绵羊用涂有磺胺嘧啶和氯己定银的气管插管插管并机械通气24 h时,气管插管、脱水器或机械通气机的吸气和呼气管路中均无细菌生长。这一初步发现是首次报告MV 24小时后呼吸机回路中无细菌生长。 4.结合我们早期的研究结果显示,当气管和气管插管低于水平方向时,气管和肺部没有细菌生长,我们的研究结果表明,在机械通气期间采取预防措施,这对于确定呼吸机系统以及上呼吸道和下呼吸道是否存在细菌定植非常重要。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

THEODOR KOLOBOW其他文献

THEODOR KOLOBOW的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('THEODOR KOLOBOW', 18)}}的其他基金

SPONTANEOUS AIRWAY PRESSURE RELEASE VENTILATION (S-APRV): A NEW CONCEPT
自主气道压力释放通气 (S-APRV):一个新概念
  • 批准号:
    6290400
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Ventilator-Associated Pneumonia. Bactericidal Tracheal T
呼吸机相关肺炎。
  • 批准号:
    6809649
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Ventilator-Associated Pneumonia. Bactericidal Trachea
呼吸机相关肺炎。
  • 批准号:
    6966902
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Ventilator-Associated Pneumonia. Mucus Slurper. Mucucili
呼吸机相关肺炎。
  • 批准号:
    7321558
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Ventilator-Associated Pneumonia. Mucus Slurper. Mucucili
呼吸机相关肺炎。
  • 批准号:
    7154386
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Spontaneous Airway Pressure Release Ventilation (s-aprv)
自主气道压力释放通气 (s-aprv)
  • 批准号:
    6541691
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SPONTANEOUS AIRWAY PRESSURE RELEASE VENTILATION (S-APRV). NOSOCOMIAL PNEUMONIA.
自主气道压力释放通气 (S-APRV)。
  • 批准号:
    6432666
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Imaging nanophysical properties of actively transporting bronchial mucus
主动输送支气管粘液的纳米物理特性成像
  • 批准号:
    9178311
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了