Ultrasonic System for Cardiac Imaging in Small Animals

用于小动物心脏成像的超声系统

• 批准号: 6901645
• 负责人: K KIRK SHUNG
• 金额: $ 29.38万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6901645
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; heart imaging /visualization /scanning; laboratory mouse; laboratory rat; phantom model; portable biomedical equipment

DESCRIPTION (provided by applicant): The objective of the proposed project is to develop a real time high frequency ultrasound imaging system capable of pulsed Doppler with a frame rate higher than 150 Hz for cardiac applications in small animals. Ultrasound imaging is a well established technology for cardiac imaging on humans. For cardiac imaging in small animals whose hearts beat at a rate higher than 200 beats/minute, the spatial and temporal resolutions of current clinical ultrasonic scanners are far from ideal and simply inadequate for such applications. Furthermore current commercial high frequency ultrasonic scanners developed for small animal imaging and eye imaging in humans are incapable of producing images at a frame rate higher than 30 Hz. The device to be designed and fabricated will be a mechanical sector scanner with a single element transducer capable of imaging the heart of small animals at a frequency from 30 to 50 MHz at a frame rate of at least 150 Hz. The proposed scanner will consist of a probe and an imaging unit that will be based on existing technology and commercial components. The design and fabrication of the probe will be the heart of the project. It will be developed in collaboration with Capistrano Lab by integrating a single element high frequency transducer with an f-number of 2 to 4 with a servo motor system. The USC group has expertise in transducer engineering and imaging system development whereas Capistrano labs Inc. has produced a similar probe which is commercially available but at a lower frame rate. The probe will be designed and built at Capistrano. The imaging unit, the Pulsed Doppler unit, and transducers will be designed and built at USC. System integration of the probe and the imaging console will also be carried out at USC. Upon the completion of this research it is expected that a prototype system will be designed and tested on wire and flow phantoms, excised mouse hearts in vitro and live animals in vivo.

描述（由申请人提供）： 拟议项目的目标是开发一个真实的时间高频超声成像系统，能够脉冲多普勒的帧速率高于150赫兹的小动物心脏应用。超声成像是用于人类心脏成像的成熟技术。对于心脏以高于200次/分钟的速率跳动的小动物的心脏成像，当前临床超声扫描仪的空间和时间分辨率远不理想，并且根本不足以用于这样的应用。此外，目前为小动物成像和人类眼睛成像而开发的商用高频超声扫描仪不能以高于30 Hz的帧速率产生图像。 拟设计和制造的设备将是一个机械扇形扫描仪，带有一个单元件换能器，能够以30至50 MHz的频率和至少150 Hz的帧频对小动物的心脏进行成像。 拟议的扫描仪将包括一个探头和一个成像单元，将以现有技术和商业部件为基础。探测器的设计和制造将是该项目的核心。它将与Capistrano实验室合作开发，通过将f数为2至4的单元件高频传感器与伺服电机系统集成。南加州大学集团在传感器工程和成像系统开发方面拥有专业知识，而Capistrano labs Inc.已经生产了一种类似的探头，该探头是商业上可获得的，但是具有较低的帧速率。探测器将在卡皮斯特拉诺设计和制造。成像单元、脉冲多普勒单元和换能器将在南加州大学设计和制造。探头和成像控制台的系统集成也将在南加州大学进行。在完成这项研究后，预计将设计一个原型系统，并在金属丝和流动模型，离体小鼠心脏和活体动物体内进行测试。