Development of a High Frame Rate Ultrasound System for Cardiac Imaging in Small A

开发用于小 A 心脏成像的高帧率超声系统

• 批准号: 7591066
• 负责人: K KIRK SHUNG
• 金额: $ 39.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591066
• 关键词: Amplifiers; Anatomy; Animals; Biomedical Research; Bite; Cardiac; Clinical; Code; Collaborations; Computer Systems Development; Computers; Development; Devices; Disease; Elements; Eye; Financial compensation; Frequencies; Funding; Genotype; Goals; Grant; Heart; Heart Diseases; Heart Rate; Hospitals; Housing; Human; Image; Image Guided Biopsy; Injection of therapeutic agent; Longitudinal Studies; Measurement; Mechanics; Methods; Monitor; Motion; Motor; Mus; Needles; Pediatric Hospitals; Penetration; Performance; Phenotype; Physiologic Monitoring; Physiological; Rattus; Research; Research Personnel; Resolution; Resources; Sampling; Scanning; Study models; System; Technology; Testing; Time; Transducers; Ultrasonics; Ultrasonography; United States National Institutes of Health; Weight; Zebrafish; analog; base; design; digital; digital imaging; drug development; heart dimension/size; heart imaging; human disease; improved; in vivo; light weight; medical schools; motor control; outcome forecast; public health relevance; research study; therapy development

DESCRIPTION (provided by applicant): The objective of the proposed project is to develop a real time high frequency ultrasound imaging system with a frame rate at a minimum of 180 Hz for cardiac applications in small animals. Ultrasound imaging is a well established technology for cardiac imaging on humans. For cardiac imaging in small animals whose hearts beat at a rate higher than 400 beats/minute, the spatial and temporal resolutions of current clinical ultrasonic scanners are far from ideal and simply inadequate for such applications. Furthermore currently there are no commercial high frequency ultrasonic scanners developed for small animal imaging and eye imaging in humans that are capable of a frame rate higher than 30 Hz over a large field of view. Under the support of this grant a device which a mechanical sector scanner with a single element transducer capable of imaging the heart of a small animal at a frequency from 30 to 50 MHz at a frame rate at a minimum of 130 Hz has been designed, fabricated, and tested. Initial experiments performed on mice and zebrafish hearts. In the next grant period, the performance of the scanner will be further improved by increasing the frequency and frame rate and implementing coded excitation to increase the depth of penetration. Miniature light weight annular arrays which allow dynamic focusing will be developed to replace single element transducers for improved spatial resolution taking advantage of an annular array based digital imaging system being developed at the USC Transducer Resource. The servo-motor based mechanical probe will be developed in collaboration with Capistrano Lab. Potential applications of this device in quantitative measurements of cardiac anatomy and physiological functions in mice and zebrafish will be explored in collaborations with investigators from USC Children's Hospital and Medical School. PUBLIC HEALTH RELEVANCE: Project Narrative Small animals, including mice, rats, zebrafish, etc., have emerged as ideal models for the study of human diseases and drug development. Therefore, as the demand for the studies of small animals increases, so does the need for methods to accurately monitor physiological and functional activities on a small scale. The high frequency ultrasonic system will offer a multitude of opportunities for biomedical research.

描述（由申请人提供）：拟议项目的目标是开发一种真实的实时高频超声成像系统，其帧速率至少为180 Hz，用于小动物的心脏应用。超声成像是用于人类心脏成像的成熟技术。对于心脏以高于400次/分钟的速率跳动的小动物的心脏成像，当前临床超声扫描仪的空间和时间分辨率远非理想，并且根本不足以用于此类应用。此外，目前还没有为小动物成像和人类眼睛成像开发的能够在大视场上具有高于30 Hz的帧速率的商用高频超声扫描仪。在该基金的支持下，设计、制造和测试了一种设备，该设备具有能够以30至50 MHz的频率和至少130 Hz的帧率对小动物心脏成像的单元件换能器的机械扇区扫描仪。在小鼠和斑马鱼心脏上进行的初步实验。在下一个资助期内，扫描仪的性能将进一步改善，方法是提高频率和帧速率，以及实施编码激发以增加穿透深度。将开发允许动态聚焦的小型轻质环形阵列，以取代单元件换能器，从而利用USC换能器资源正在开发的基于环形阵列的数字成像系统来提高空间分辨率。基于伺服电机的机械探针将与Capistrano Lab合作开发。将与南加州大学儿童医院和医学院的研究人员合作，探索该设备在定量测量小鼠和斑马鱼心脏解剖结构和生理功能方面的潜在应用。公共卫生相关性：项目叙述小动物，包括小鼠、大鼠、斑马鱼等，已经成为研究人类疾病和药物开发的理想模型。因此，随着对小动物研究需求的增加，对小规模精确监测生理和功能活动的方法的需求也在增加。高频超声系统将为生物医学研究提供大量机会。