Personalised pulsed-ultrasound to promote bone fracture healing

个性化脉冲超声促进骨折愈合

• 批准号: 2603371
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2603371
• 关键词: Personalised; pulsed; ultrasound; promote; bone

This project will make use of our established in vitro experimental systems and state of the art laser Doppler vibrometry to investigate the micro-motion and nano-displacements induced by low-intensity, pulsed-ultrasound waves as they interact with osteoblast cells lines and bone tissue phantoms. Acoustic simulation (OnScale) will be used to establish the resulting forces imposed on the cells and tissues involved and how these are influenced by the propagation environment (anatomy) and drive parameters employed (frequency, acoustic pressure, etc). With clinical support, the student will use the data gathered to design more effective ultrasound devices, capable of delivering controlled low-intensity, pulsed-ultrasound fields to promote fracture healing across a range of presentations. In addition to the clear prospects offered by successfully advancing the technology, we anticipate potential commercialisation opportunities once we can demonstrate that optimisation of the field to suit the individual presents a significant healing advantage.

该项目将利用我们建立的体外实验系统和最先进的激光多普勒测振仪来研究低强度脉冲超声波与成骨细胞系和骨组织模型相互作用时引起的微运动和纳米位移。声学模拟 (OnScale) 将用于确定施加在相关细胞和组织上的力，以及这些力如何受到传播环境（解剖学）和所使用的驱动参数（频率、声压等）的影响。在临床支持下，学生将利用收集到的数据设计更有效的超声设备，能够提供受控的低强度脉冲超声场，以在一系列演示中促进骨折愈合。除了成功推进该技术提供的明确前景之外，一旦我们能够证明适合个人的领域优化具有显着的治疗优势，我们预计潜在的商业化机会。