Personalised pulsed-ultrasound to promote bone fracture healing

该项目将利用我们建立的体外实验系统和最先进的激光多普勒测振仪来研究低强度脉冲超声波与成骨细胞系和骨组织模体相互作用时诱导的微动和纳米位移。声学模拟(OnScale)将用于确定施加在所涉及的细胞和组织上的合力，以及传播环境(解剖结构)和所采用的驱动参数(频率、声压等)对这些力的影响。在临床支持下，学生将使用收集的数据来设计更有效的超声设备，能够提供受控的低强度脉冲超声场，以促进一系列演示的骨折愈合。除了成功推进技术提供的明确前景外，我们预计，一旦我们能够证明优化领域以适合个人带来显著的治愈优势，就会有潜在的商业化机会。

This project will make use of our established in vitro experimental systems and state of the art laser Doppler vibrometry to investigate the micro-motion and nano-displacements induced by low-intensity, pulsed-ultrasound waves as they interact with osteoblast cells lines and bone tissue phantoms. Acoustic simulation (OnScale) will be used to establish the resulting forces imposed on the cells and tissues involved and how these are influenced by the propagation environment (anatomy) and drive parameters employed (frequency, acoustic pressure, etc). With clinical support, the student will use the data gathered to design more effective ultrasound devices, capable of delivering controlled low-intensity, pulsed-ultrasound fields to promote fracture healing across a range of presentations. In addition to the clear prospects offered by successfully advancing the technology, we anticipate potential commercialisation opportunities once we can demonstrate that optimisation of the field to suit the individual presents a significant healing advantage.