Low intensity pulsed ultrasound to treat chronic wounds caused by DTI in prosthetic wearers

低强度脉冲超声波治疗假肢佩戴者因 DTI 引起的慢性伤口

• 批准号: 2883716
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2883716
• 关键词: Low; intensity; pulsed; ultrasound; treat

Project Description Wound healing itself is relatively well understood, however the evolution and progression pathway associated with deep tissue injury in prosthesis wearers, is less well defined. Meanwhile the impact of DTI and potential chronic wound development on the individual is heightened by an absence of available treatments, with advice dominated by approaches that severely impact mobility and independence. Ultrasound imaging is unique in its ability to image the soft tissues, with sufficient sensitivity to accurately distinguish tissue boundaries and even muscle fibre orientation. The dependence of ultrasound wave propagation within tissue as a viscoelastic medium means that tissue stiffness information is also readily recovered, using either elastography (strain) or shear wave imaging. In the future it is expected that ultrasound imaging will play an important role in detecting early-stage alterations in tissue microsctructure indicative of DTI initiation and existence. The proposed work builds upon existing academic and clinical expertise in experimental medical imaging, soft tissue mechanics, computational modelling and lower limb prosthetic socket design to investigate the feasibility of enhancing socket design by understanding the evolution of Deep Tissue Injury. The project will develop techniques that will utilise newly emerging flexible ultrasound technologies capable of delivering pulsed-ultrasound through a wearable patch. The proposed PhD research is well aligned with the health engineering strategy of this CDT and fits well with the strategic activities within the University of Strathclyde. The proposed PhD research aims to generate a knowledge base that will play an important role in the development of innovative medical solutions that are becoming critical to sustain the quality of life of an aging UK society. Additionally, the prospective project is within the preventive healthcare domain and has the potential to allow for cost reduction in stretched financial resources of NHS and promotes earlier and accurate targeted treatment with prevention of injury.

项目简介创伤愈合本身已被较好地了解，然而与假体佩戴者深层组织损伤相关的进化和进展途径还不是很清楚。与此同时，DTI和潜在的慢性伤口发展对个体的影响因缺乏可用的治疗而加剧，建议以严重影响活动能力和独立性的方法为主。超声成像的独特之处在于其成像软组织的能力，具有足够的灵敏度来准确区分组织边界，甚至肌肉纤维方向。超声波作为粘弹性介质在组织内传播的相关性意味着，使用弹性成像(应变)或剪切波成像也可以很容易地恢复组织的硬度信息。在未来，超声成像将在检测组织微结构的早期改变方面发挥重要作用，这表明DTI的启动和存在。这项拟议的工作建立在现有的学术和临床专业知识的基础上，在实验医学成像、软组织力学、计算建模和下肢假肢接受腔设计方面，通过了解深部组织损伤的演变来研究加强接受腔设计的可行性。该项目将开发利用新出现的柔性超声波技术的技术，这些技术能够通过可穿戴式贴片传递脉冲超声波。拟议的博士研究与CDT的健康工程战略很好地结合在一起，并与斯特拉斯克莱德大学的战略活动很好地吻合。拟议的博士研究旨在生成一个知识库，该知识库将在创新医疗解决方案的开发中发挥重要作用，这些解决方案对维持老龄化英国社会的生活质量至关重要。此外，预期的项目属于预防保健领域，有可能降低NHS紧张的财政资源的成本，并促进早期和准确的针对性治疗和预防伤害。