Pyk2 Signaling In Intestinal Epithelial Cells

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CONTINUATIONPAGE Principal Investigator/PrograrnDirector (Last, first,middle): Wu, Steven Shi-fong 5. Environmental and Institutional Commitmentto the Candidate a. Description of the Institutional Environment In addition to direct mentoring from Dr. Enrique Rozengurt in the fields of signal transduction and growth regulation, Dr. Wu will benefit from the advice and guidance of his ScientificAdvisory Committee, consisting of myself, Dr. Martin Martin, Associate Professor in the Division of Gastroenterology, and Dr. Sherin Devaskar, Professor, Chiefof the Division ofNeonatology, and Vice Chair for Research. We are all very committed to mentoring fellows and young faculty. Dr. Linda McCabe and I have been offering an annual course, How to Succeed in Academics, since 1991,and we have published a book of the sametitle. We also initiated a Leadership Workshop beginning in 1996. We are absolutely committed to mentoring and Dr. Wu's committee exemplifies individuals for whom this is a central value. Since being recruited to the UCLA faculty in 1997, Dr. Rozengurt has been the recipient of three NIDDK R01 grants and a section of an NCI P50 SPORE institutional project grant, and has established an outstanding and productive laboratory group within the Division of Digestive Diseases, Department of Medicine. In addition to Dr. Wu, this laboratory group includes four graduate students of whom three are post-M.D. fellows, eight postdoctoral Ph.D. fellows, three part-time undergraduate students, one research associate, and one technician. The laboratory covers 5,000 square feet on the first floor of Warren Hall, which houses research space for the Department of Nutrition and several divisions of the Department of Medicine. The laboratory is fully equipped for signal transduction research with two cell culture hoods, multiple incubators, refrigerators, and freezers including liquid nitrogen cell storage, as well as equipment for protein and nucleotide electrophoresis and gel transfer. There is a spectrophotometer for measuring intracellular calcium flux, a darkroom with an X-ray film developing machine, and a separate room for radioactive work and storage, and including a liquid scintillation counter. The laboratory shares access within the building to a high resolution videomicroscopy system and elsewhere on the UCLA campus to the core resources of the Molecular Biology Institute, including confocal microscopy equipment, and of the CURE/Digestive Diseases Research Center. As an important part of his career development and training, Dr. Wu has previously attended our two- day workshop on How to Succeed in Academics, and will attend a future one-day workshop on Academic Leadership, in addition to a series of weekly noon conferences developed by Dr. Devaskar. These conferences rotate between the following topics: Didactic training in establishing a successful research career; a work-in-progress seminar with presentations by fellows andjunior faculty; a departmental research seminar presented by senior faculty; and a pediatric researchjournal club. He will also attend a weekly Division of Digestive Diseasesjournal club and a biweekly Signal Transduction Group seminar. He will enroll in the graduate level courses outlined in the Candidate Background section of his proposal, which will enrich his understanding of molecular biology and genetics. He will continue to present his research in lab meetings, departmental meetings, and at national meetings such as those of the American Gastroenterological Association (Digestive Disease Week) and ofthe North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN). This combination of resources, from both Dr. Rozengurt's laboratory and the Department of Pediatrics, will provide the intellectual and physical resources for a supportive and stimulatingtraining program for Dr. Wu, as have been provided for many of our previous trainees who are successful in academic medicine. In my experience with previous trainees at UCLA and other institutions,trainees with Dr. Wu's background, skills, and motivation have become truly superb physician-scientists. A KO8 grant will be instrumental in launching his academic career. As Chair of the Department of Pediatrics, I will continue to protect his research time at 80% throughout his five-year tenure on the K08, and beyond, if he elects to remain at UCLA. I am confident that Dr. Wu will be productive and innovative in his approach to research, and will continue to develop into an outstanding independent physician-scientist in the field ofpediatric gastroenterology. PHS 398 (Rev. 4/98) Page 21 Use %-inch MARGINS. Number pages consecutively at the bottomthroughout the application. Domusesuffixes such as 3a, 3b. ========================================Section End===========================================