Gut Ischemia/Reperfusion Injury: Modulation by Nutrients

肠道缺血/再灌注损伤:营养素的调节

基本信息

项目摘要

DESCRIPTION (provided by applicant): Candidate: Dr. Kozar is a new faculty member at the University of Texas-Houston Medical School (UTHMS), where she is a member of the Department of Surgery. She first acquired basic research skills as a NRSA Fellow while obtaining her PhD at Baylor College of Medicine. Following completion of her general surgery training, the candidate accepted a faculty position in Trauma and Critical Care at MCP-Hahnemann University School of Medicine under the direction of Dr. Joel Rosyln. During this time she began to develop research experience in the field of Trauma and Critical Care by investigating the activity of antioxidant enzymes in an acute lung injury model, funded by a private grant for which she was the principal investigator. Since becoming a faculty member in the Department of Surgery at UTHMS she has become very active in the NIGMS-sponsored Trauma Research Center, focusing on the role of the gut in multiple organ failure. A Career Development Award, in conjunction with the support of two highly respected mentors, would enhance the acquisition of the necessary skills and talents crucial to becoming a future independent investigator. Research: The proposed research project is an extension of the Trauma Research Center?s interest in the link between gut dysfunction and multiple organ failure. As proposed in this application, the candidate wilt test the hypothesis that specific enterat nutrients during gut ischemia/reperfusion impair gut function and enhance gut injury. The goal of the proposed project is to understand how enterat nutrients during times of metabolic stress can be detrimental to gut function. The results obtained will facilitate a better understanding of postinjury gut dysfunction and aide in future strategies to achieve enteral tolerance in patients at high risk for multiple organ failure. Environment: The UTHMS in the center of the Texas Medical Center is comprised of 42 member institutions dedicated not only to outstanding patient care but also to the highest standards and quality of research. As part of the Department of Surgery's Trauma Research Center, the candidate has the guidance and support of numerous researchers in the Department of Surgery as well as in Integrative Biology, and Medicine. The sponsors are an integral part of this arrangement and are especially suited to ensure success of the proposed project.
描述(由申请人提供):候选人:Kozar博士是一名新教员

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Rosemary A Kozar其他文献

The Contribution of Corn Trypsin Inhibitor on Thrombin Generation Kinetics in Trauma Patients: A Comparative Analysis
  • DOI:
    10.1182/blood-2024-201035
  • 发表时间:
    2024-11-05
  • 期刊:
  • 影响因子:
  • 作者:
    Sergio M Navarro;Riley J. Thompson;Grant M Spears;Kent R Bailey;Jing-Fei Dong;Rosemary A Kozar;Dong Chen;Rajiv K Pruthi;Myung S Park
  • 通讯作者:
    Myung S Park

Rosemary A Kozar的其他文献

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{{ truncateString('Rosemary A Kozar', 18)}}的其他基金

Endothelial injury and repair following hemorrhagic shock
失血性休克后的内皮损伤与修复
  • 批准号:
    9767269
  • 财政年份:
    2018
  • 资助金额:
    $ 11.93万
  • 项目类别:
Endothelial injury and repair following hemorrhagic shock
失血性休克后的内皮损伤与修复
  • 批准号:
    10164803
  • 财政年份:
    2018
  • 资助金额:
    $ 11.93万
  • 项目类别:
Syndecan shedding after trauma and hemorrhagic shock
外伤和失血性休克后多配体脱落
  • 批准号:
    9067397
  • 财政年份:
    2013
  • 资助金额:
    $ 11.93万
  • 项目类别:
Syndecan shedding after trauma and hemorrhagic shock
外伤和失血性休克后多配体脱落
  • 批准号:
    8731257
  • 财政年份:
    2013
  • 资助金额:
    $ 11.93万
  • 项目类别:
Syndecan shedding after trauma and hemorrhagic shock
外伤和失血性休克后多配体脱落
  • 批准号:
    8562235
  • 财政年份:
    2013
  • 资助金额:
    $ 11.93万
  • 项目类别:
Syndecan shedding after trauma and hemorrhagic shock
外伤和失血性休克后多配体脱落
  • 批准号:
    9056747
  • 财政年份:
    2013
  • 资助金额:
    $ 11.93万
  • 项目类别:
Induction of molecular Mediators by Enteral Nutrients in the Postischemic Gut
缺血后肠道肠内营养物诱导分子介质
  • 批准号:
    7487950
  • 财政年份:
    2007
  • 资助金额:
    $ 11.93万
  • 项目类别:
Induction of molecular Mediators by Enteral Nutrients in the Postischemic Gut
缺血后肠道肠内营养物诱导分子介质
  • 批准号:
    7260240
  • 财政年份:
    2007
  • 资助金额:
    $ 11.93万
  • 项目类别:
Induction of molecular Mediators by Enteral Nutrients in the Postischemic Gut
缺血后肠道肠内营养物诱导分子介质
  • 批准号:
    7641116
  • 财政年份:
    2007
  • 资助金额:
    $ 11.93万
  • 项目类别:
Induction of molecular Mediators by Enteral Nutrients in the Postischemic Gut
缺血后肠道肠内营养物诱导分子介质
  • 批准号:
    7870260
  • 财政年份:
    2007
  • 资助金额:
    $ 11.93万
  • 项目类别:

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Gut microbial metabolite- Trimethylamine-N-oxide and endothelial inflammasome signaling in cardiovascular injury
肠道微生物代谢物-三甲胺-N-氧化物和心血管损伤中的内皮炎性体信号传导
  • 批准号:
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P2X7受体在血管紧张素II诱导的高血压和心血管损伤中的作用
  • 批准号:
    386428
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    2017
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Project 2: Cardiovascular Injury Due to Tobacco Use
项目 2:吸烟引起的心血管损伤
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    8595393
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    $ 11.93万
  • 项目类别:
Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
使用 CPAP 治疗心血管损伤的可逆性:涉及的机制
  • 批准号:
    7787358
  • 财政年份:
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    $ 11.93万
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Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
使用 CPAP 治疗心血管损伤的可逆性:涉及的机制
  • 批准号:
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Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
使用 CPAP 治疗心血管损伤的可逆性:涉及的机制
  • 批准号:
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  • 财政年份:
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  • 项目类别:
Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
使用 CPAP 治疗心血管损伤的可逆性:涉及的机制
  • 批准号:
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  • 财政年份:
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  • 项目类别:
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心血管损伤与修复研究设施
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    7000233
  • 财政年份:
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铁介导的心血管损伤
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    2233848
  • 财政年份:
    1996
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    $ 11.93万
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IRON MEDIATED CARDIOVASCULAR INJURY
铁介导的心血管损伤
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  • 财政年份:
    1996
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