Gut Ischemia/Reperfusion Injury: Modulation by Nutrients

肠道缺血/再灌注损伤：营养素的调节

• 批准号: 6644243
• 负责人: Rosemary A Kozar
• 金额: $ 11.93万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-10 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644243
• 关键词: artery occlusion; cardiovascular injury; disease /disorder model; disease /disorder proneness /risk; electrophysiology; enzyme activity; fluorescence microscopy; gastrointestinal absorption /transport; gastrointestinal function; gastrointestinal nutrient absorption; gene expression; hemorrhagic shock; immunofluorescence technique; intestinal mucosa; ischemia; laboratory rat; laparoscopy; membrane permeability; mesenteric artery; multiple organ failure; polymerase chain reaction; reperfusion; sodium potassium exchanging ATPase; ultrasound blood flow measurement; western blottings

DESCRIPTION (provided by applicant): Candidate: Dr. Kozar is a new faculty member at the University of Texas-Houston Medical School (UTHMS), where she is a member of the Department of Surgery. She first acquired basic research skills as a NRSA Fellow while obtaining her PhD at Baylor College of Medicine. Following completion of her general surgery training, the candidate accepted a faculty position in Trauma and Critical Care at MCP-Hahnemann University School of Medicine under the direction of Dr. Joel Rosyln. During this time she began to develop research experience in the field of Trauma and Critical Care by investigating the activity of antioxidant enzymes in an acute lung injury model, funded by a private grant for which she was the principal investigator. Since becoming a faculty member in the Department of Surgery at UTHMS she has become very active in the NIGMS-sponsored Trauma Research Center, focusing on the role of the gut in multiple organ failure. A Career Development Award, in conjunction with the support of two highly respected mentors, would enhance the acquisition of the necessary skills and talents crucial to becoming a future independent investigator. Research: The proposed research project is an extension of the Trauma Research Center?s interest in the link between gut dysfunction and multiple organ failure. As proposed in this application, the candidate wilt test the hypothesis that specific enterat nutrients during gut ischemia/reperfusion impair gut function and enhance gut injury. The goal of the proposed project is to understand how enterat nutrients during times of metabolic stress can be detrimental to gut function. The results obtained will facilitate a better understanding of postinjury gut dysfunction and aide in future strategies to achieve enteral tolerance in patients at high risk for multiple organ failure. Environment: The UTHMS in the center of the Texas Medical Center is comprised of 42 member institutions dedicated not only to outstanding patient care but also to the highest standards and quality of research. As part of the Department of Surgery's Trauma Research Center, the candidate has the guidance and support of numerous researchers in the Department of Surgery as well as in Integrative Biology, and Medicine. The sponsors are an integral part of this arrangement and are especially suited to ensure success of the proposed project.

描述（由申请人提供）：候选人：博士Kozar是一个新的教师 她是德克萨斯大学休斯顿医学院（UTHMS）的成员， 外科医生她首先获得了基本的研究技能 在贝勒医学院获得博士学位时，她是NRSA的研究员。 在完成普通外科培训后，该候选人接受了 哈内曼大学医学院创伤与重症监护系教授 Joel Rosyln博士的指导下进行的。在此期间，她开始 发展创伤和重症监护领域的研究经验， 研究急性肺损伤中抗氧化酶的活性 模型，由私人赠款资助，她是首席研究员。 自从成为UTHMS外科系的一名教员以来，她 在NIGMS赞助的创伤研究中心变得非常活跃，专注于 肠道在多器官衰竭中的作用职业发展奖，在 在两位德高望重的导师的支持下， 获得对成为未来至关重要的必要技能和人才 独立调查员研究：拟议的研究项目是一个 创伤研究中心的扩建我们对肠道和 功能障碍和多器官衰竭。如本申请中所提出的， 候选人将检验以下假设： 缺血/再灌注损害肠功能并增强肠损伤。的目标 拟议的项目是为了了解如何进入营养素在时间的 代谢应激可能对肠道功能有害。获得的结果将 有助于更好地理解损伤后肠道功能障碍， 在高风险患者中实现肠内耐受的未来策略 多器官衰竭环境：德克萨斯州中心的UTHMS 医疗中心由42个成员机构组成，不仅致力于 卓越的病人护理，同时也达到最高标准和质量， research.作为外科创伤研究中心的一部分， 候选人有许多研究人员的指导和支持， 外科学系以及综合生物学和医学系。的 赞助商是这种安排的一个组成部分，特别适合于 确保拟议项目的成功。