How Does Osteocalcin Reverse Glucocorticoid-Induced Dysmetabolism?

糖皮质激素（GCs）的益处经常被骨质流失、糖尿病和肥胖等副作用所损害。现在有证据表明骨钙素调节燃料代谢。因此，骨钙素可能是预防GC治疗不良代谢影响的潜在靶点。我们的目的是确定骨钙素在GC过量条件下如何调节脂肪组织和肝脏的能量代谢，以及骨钙素是否以及如何通过g蛋白偶联受体起作用。

The benefits of glucocorticoids (GCs) are often compromised by adverse effects such as bone loss, diabetes & obesity. There is now evidence that osteocalcin regulates fuel metabolism. Osteocalcin may therefore be a potential target to prevent the adverse metabolic effects of GC therapy. We aim to determine how osteocalcin regulates energy metabolism in adipose tissue and the liver under conditions of GC excess, and whether and how osteocalcin acts through a G-protein coupled receptor.