Overcoming transport barriers for multistage delivery of extracellular vesicles in oncology

克服肿瘤学中细胞外囊泡多阶段递送的运输障碍

• 批准号: 2604828
• 金额: --
• 依托单位: Swansea University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2604828
• 关键词: Overcoming; transport; barriers; multistage; delivery

Sponsored by the Engineering and Physical Sciences Research Council (EPSRC), the project aims to develop novel biomimetic drug-delivery approaches for gynaecological cancers. Using multi-scale depot approaches, these advanced delivery methods will be able to preferentially accumulate at metastatic sites and maintain the bioactivity of therapeutic payloads. Multistage porous particles (MSV) will be used for localized delivery of nanoparticles and cytotoxic drugs, to modulate target cell function and rewire malignant processes.

该项目由工程和物理科学研究理事会（EPSRC）赞助，旨在为妇科癌症开发新的仿生药物输送方法。使用多尺度储库方法，这些先进的递送方法将能够优先在转移部位累积并保持治疗有效载荷的生物活性。多级多孔颗粒（MSV）将用于纳米颗粒和细胞毒性药物的局部递送，以调节靶细胞功能并重新连接恶性过程。