Elucidating the role of Fam20C in microglia cells during homeostasis and neurodevelopment

阐明 Fam20C 在小胶质细胞稳态和神经发育过程中的作用

• 批准号: 2605425
• 金额: --
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2605425
• 关键词: Elucidating; role; Fam20C; microglia; cells

This project aims to uncover the function of the secreted kinase, Fam20C, in microglia cells; and how disruption of FAM20C may lead to dysregulation of microglial function in brain homeostasis and neurodevelopment. This proposal is within the MRC's remit of furthering knowledge on molecular and cellular mechanisms in neuroscience. This project will use an interdisciplinary approach by employing phosphoproteomics, biochemistry, genome editing in ex-vivo microglia and a mouse model to determine Fam20C molecular, cellular, and neurological microglial functions.The potential outcome of this study is an improvement on our understanding of how the phosphor-secretome in microglia cells regulate microglial function in the context of neurodevelopment and disease.

该项目旨在揭示小胶质细胞中分泌激酶 Fam20C 的功能；以及 FAM20C 的破坏如何导致大脑稳态和神经发育中小胶质细胞功能失调。该提案属于 MRC 的职责范围，旨在进一步加深对神经科学分子和细胞机制的了解。该项目将采用跨学科方法，通过采用磷酸蛋白质组学、生物化学、离体小胶质细胞基因组编辑和小鼠模型来确定 Fam20C 分子、细胞和神经小胶质细胞功能。这项研究的潜在结果是提高我们对小胶质细胞中的磷分泌组如何在神经发育和疾病背景下调节小胶质细胞功能的理解。