Neuroimaging Research Center: High Field Facility

描述(由申请人提供)：根据NCRR RFA RR-03-009的要求，本提案要求提供资金，以分担购买3.0特斯拉先进一代大口径磁共振成像(MRI)扫描仪的费用，以支持达特茅斯医学院和学院、达特茅斯希区柯克医学中心(DHMC)和塞耶工程学院的多个人类和动物健康相关研究项目。一个校园范围内的多学科研究联盟，每年有超过1500万美元的成像相关赞助研究，迫切需要获得最先进的高场扫描能力，以实现当前和新兴的科学目标。一项详细的技术研究检查了研究人员在场强、梯度和射频线圈并行成像、软件集成和其他功能方面所需的关键功能。建议的NRC的主要代表用户群包括：(1)衰老和阿尔茨海默病；(2)焦虑症治疗；(3)生物信息学和图像分析；(4)生物物理学、生物工程和放射学研究计划；(5)脑损伤研究计划：人和动物模型；(6)心血管成像和血管生成中心；(7)认知神经科学计划；(8)癫痫和功能神经外科；(9)多发性硬化症中心；(10)神经肿瘤、放射和化疗成像研究；(11)儿科精神药理学；(12)精神分裂症、情感障碍和药物滥用研究；(13)脊柱和肌肉骨骼临床研究中心；(14)其他使用者、试验计划和培训补助金/奖学金计划。NRC将被广泛使用，并由经验丰富的团队进行管理。它将成为自给自足的，并极大地提高许多领先研究人员的科学生产力。它还将促进对未来生物医学科学家的培训。

DESCRIPTION (provided by applicant): This proposal, in response to the NCRR RFA RR-03-009, requests funds to cost share the purchase of a 3.0 Tesla advanced generation large bore magnetic resonance imaging (MRI) scanner to support multiple programs of human and animal health-related research at Dartmouth Medical School and College, Dartmouth Hitchcock Medical Center (DHMC) and the Thayer School of Engineering. A campus wide multidisciplinary consortium of investigators with over $15M in annual imaging related sponsored research urgently requires access to state of the art high field scanning capability to accomplish current and emerging scientific goals. A detailed technical study examined the critical features needed by investigators in terms of field strength, gradients, and radiofrequency coils parallel imaging, software integration and other features. Representative Major User Groups for the proposed NRC include: (1) Aging and Alzheimer's Disease; (2) Anxiety Disorders Treatment; (3) Bioinformatics and Image Analysis; (4) Biophysics, Bioengineering and Radiological Research Programs; (5) Brain Injury Research Programs: Human and Animal Models; (6) Cardiovascular Imaging and Angiogenesis Centers; (7) Cognitive Neuroscience Program; (8) Epilepsy and Functional Neurosurgery; (9) Multiple Sclerosis Center; (10) Neuro-Oncology, Radiation and Chemotherapy Imaging Studies; (11) Pediatric Psychopharmacology; (12) Schizophrenia, Affective Disorders and Substance Abuse Research; (13) Spine and Musculoskeletal Clinical Research Centers; (14) Other Users, Pilot Projects and Training Grants/Fellowship Programs. The NRC will be extensively utilized and administered by an experienced team. It will become self-sufficient and greatly enhance the scientific productivity of many leading investigators. It will also facilitate the training of future biomedical scientists.