Ultra High Field 9.4T Animal Magnetic Resonance Scanner

超高场9.4T动物磁共振扫描仪

• 批准号: 6730865
• 负责人: Marc J Kaufman
• 金额: $ 50万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6730865
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; functional magnetic resonance imaging; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): This Shared Instrumentation Grant requests funds to support purchase of an ultra high field 9.4 Tesla magnetic resonance scanner for nonhuman primate and rodent studies of human health and disease, to be located within the McLean Hospital Brain Imaging Center. McLean Hospital is the largest Harvard-affiliated psychiatric teaching hospital and supports one of the most comprehensive neuroscience research programs in the country. With the installation of a 1.5 Tesla magnetic resonance scanner in 1987, McLean became the first psychiatric facility in the world to independently own and operate a Brain Imaging Center. Subsequently, we installed a high field (4.0 Tesla) magnetic resonance scanner for research studies in 2000. The BIC research program currently includes 8 independent faculty members who are involved in collaborative imaging research studies with other investigators at McLean Hospital and several local institutions. In addition, BIC collaborations extend to other institutions in New England and across the United States. Major research interests of BIC and McLean Hospital scientists include translational research studies (human and animal models) of affective illness, aging, substance abuse, neurodegenerative disease, and technology development. The primary imaging methods employed include functional magnetic resonance imaging (fMRI) and multinuclear (proton-1, lithium-7 carbon-13, fluorine-19, sodium-23, and phosphorus-31) magnetic resonance spectroscopy (MRS). As spatial, temporal, and spectral resolution of fMRI and MRS improve with increased magnetic field strength, translational research efforts of BIC faculty, other McLean Hospital investigators, collaborators, and other regional instrument users would be substantially enhanced by installation of an ultra high field 9.4 Tesla animal scanner.

描述（由申请人提供）： 这项共享的仪器赠款要求资金支持购买超高场9.4特斯拉磁共振扫描仪，用于非人类灵长类动物和人类疾病的啮齿动物研究，该研究位于麦克莱恩医院脑成像中心内。麦克莱恩医院是哈佛最大的相关精神病医院，并支持该国最全面的神经科学研究计划之一。随着1987年安装1.5特斯拉磁共振扫描仪，麦克莱恩（McLean）成为世界上第一个独立拥有和运营脑成像中心的精神病学设施。随后，我们在2000年为研究研究了一个高领域（4.0特斯拉）磁共振扫描仪。BIC研究计划目前包括8名独立教职员工，他们与麦克莱恩医院的其他研究人员和几家当地机构一起参与了协作成像研究。此外，BIC的合作扩展到了新英格兰和整个美国的其他机构。 BIC和McLean医院科学家的主要研究兴趣包括情感疾病，衰老，药物滥用，神经退行性疾病和技术发展的转化研究（人类和动物模型）。所采用的主要成像方法包括功能磁共振成像（fMRI）和多核（Proton-1，Lithium-7 Carbon-13，Fluorine-19，氟-19，钠-23和Phosphorus-31）磁共振光谱谱光谱（MRS）。随着FMRI和MRS的空间，时间和光谱分辨率随着磁场强度的提高，BIC教师，其他麦克莱恩医院研究人员，合作者和其他区域仪器使用者的转化研究工作的提高，将通过安装超高场9.4 Tesla Animal Scanner来大大增强。

项目成果

Magnetic resonance spectroscopy studies of substance use disorders: Current landscape and potential future directions.

• DOI: 10.1016/j.pbb.2020.173090
• 发表时间: 2021-01
• 期刊: Pharmacology, biochemistry, and behavior
• 作者: Kohut SJ;Kaufman MJ
• 通讯作者: Kaufman MJ

Effects of Near-Infrared Light on Cerebral Bioenergetics Measured with Phosphorus Magnetic Resonance Spectroscopy.

用磷磁共振波谱测量近红外光对脑生物能的影响。

• DOI: 10.1089/pho.2016.4238
• 发表时间: 2017
• 期刊: Photomedicine and laser surgery
• 作者: Mintzopoulos,Dionyssios;Gillis,TimothyE;Tedford,ClarkE;Kaufman,MarcJ
• 通讯作者: Kaufman,MarcJ

Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates.

• DOI: 10.1038/s41398-020-01101-z
• 发表时间: 2020-12-02
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Kohut SJ;Mintzopoulos D;Kangas BD;Shields H;Brown K;Gillis TE;Rohan ML;Bergman J;Kaufman MJ
• 通讯作者: Kaufman MJ

Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice.

年轻成年 SAPAP3 敲除小鼠纹状体磁共振波谱异常。

• DOI: 10.1016/j.bpsc.2015.10.001
• 发表时间: 2016
• 期刊: Biological psychiatry. Cognitive neuroscience and neuroimaging
• 作者: Mintzopoulos,Dionyssios;Gillis,TimothyE;Robertson,HollyR;Dalia,Triana;Feng,Guoping;Rauch,ScottL;Kaufman,MarcJ
• 通讯作者: Kaufman,MarcJ