Ultra High Field 9.4T Animal Magnetic Resonance Scanner

描述（由申请人提供）： 这项共享仪器补助金要求资金支持购买超高场9.4特斯拉磁共振扫描仪，用于非人类灵长类动物和啮齿动物对人类健康和疾病的研究，该扫描仪将位于姆克林医院脑成像中心。姆克林医院是最大的哈佛附属精神病学教学医院，并支持该国最全面的神经科学研究项目之一。随着1987年1.5特斯拉磁共振扫描仪的安装，姆克林成为世界上第一个独立拥有和运营脑成像中心的精神病机构。随后，我们在2000年安装了一台高场（4.0特斯拉）磁共振扫描仪进行研究。BIC研究计划目前包括8名独立教师，他们与姆克林医院和几个当地机构的其他研究人员一起参与协作成像研究。此外，BIC的合作扩展到新英格兰和美国各地的其他机构。BIC和姆克林医院科学家的主要研究兴趣包括情感疾病，衰老，药物滥用，神经退行性疾病和技术开发的转化研究（人类和动物模型）。所采用的主要成像方法包括功能性磁共振成像（fMRI）和多核（质子-1、锂-7、碳-13、氟-19、钠-23和磷-31）磁共振波谱（MRS）。随着fMRI和MRS的空间、时间和光谱分辨率随着磁场强度的增加而提高，BIC教师、其他姆克林医院研究人员、合作者和其他区域仪器用户的翻译研究工作将通过安装超高场9.4特斯拉动物扫描仪而得到实质性增强。

DESCRIPTION (provided by applicant): This Shared Instrumentation Grant requests funds to support purchase of an ultra high field 9.4 Tesla magnetic resonance scanner for nonhuman primate and rodent studies of human health and disease, to be located within the McLean Hospital Brain Imaging Center. McLean Hospital is the largest Harvard-affiliated psychiatric teaching hospital and supports one of the most comprehensive neuroscience research programs in the country. With the installation of a 1.5 Tesla magnetic resonance scanner in 1987, McLean became the first psychiatric facility in the world to independently own and operate a Brain Imaging Center. Subsequently, we installed a high field (4.0 Tesla) magnetic resonance scanner for research studies in 2000. The BIC research program currently includes 8 independent faculty members who are involved in collaborative imaging research studies with other investigators at McLean Hospital and several local institutions. In addition, BIC collaborations extend to other institutions in New England and across the United States. Major research interests of BIC and McLean Hospital scientists include translational research studies (human and animal models) of affective illness, aging, substance abuse, neurodegenerative disease, and technology development. The primary imaging methods employed include functional magnetic resonance imaging (fMRI) and multinuclear (proton-1, lithium-7 carbon-13, fluorine-19, sodium-23, and phosphorus-31) magnetic resonance spectroscopy (MRS). As spatial, temporal, and spectral resolution of fMRI and MRS improve with increased magnetic field strength, translational research efforts of BIC faculty, other McLean Hospital investigators, collaborators, and other regional instrument users would be substantially enhanced by installation of an ultra high field 9.4 Tesla animal scanner.