Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates.
Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates.
复制标题
长期可卡因自我给药对非人类灵长类动物中脑静止状态功能连通性的影响。
DOI：
10.1038/s41398-020-01101-z
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发表时间：
2020-12-02
影响因子：
6.8
通讯作者：
Kaufman MJ
中科院分区：
文献类型：
--
作者：
Kohut SJ;Mintzopoulos D;Kangas BD;Shields H;Brown K;Gillis TE;Rohan ML;Bergman J;Kaufman MJ
Long-term cocaine use is associated with a variety of neural and behavioral deficits that impact daily function. This study was conducted to examine the effects of chronic cocaine self-administration on resting-state functional connectivity of the dorsal anterior cingulate (dACC) and putamen—two brain regions involved in cognitive function and motoric behavior—identified in a whole brain analysis. Six adult male squirrel monkeys self-administered cocaine (0.32 mg/kg/inj) over 140 sessions. Six additional monkeys that had not received any drug treatment for ~1.5 years served as drug-free controls. Resting-state fMRI imaging sessions at 9.4 Tesla were conducted under isoflurane anesthesia. Functional connectivity maps were derived using seed regions placed in the left dACC or putamen. Results show that cocaine maintained robust self-administration with an average total intake of 367 mg/kg (range: 299–424 mg/kg). In the cocaine group, functional connectivity between the dACC seed and regions primarily involved in motoric behavior was weaker, whereas connectivity between the dACC seed and areas implicated in reward and cognitive processing was stronger. In the putamen seed, weaker widespread connectivity was found between the putamen and other motor regions as well as with prefrontal areas that regulate higher-order executive function; stronger connectivity was found with reward-related regions. dACC connectivity was associated with total cocaine intake. These data indicate that functional connectivity between regions involved in motor, reward, and cognitive processing differed between subjects with recent histories of cocaine self-administration and controls; in dACC, connectivity appears to be related to cumulative cocaine dosage during chronic exposure.
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影响因子：
3.7
作者：
Connolly CG;Bell RP;Foxe JJ;Garavan H
通讯作者：
Garavan H
影响因子：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
4.2
作者：
Ide, Jaime S.;Zhang, Sheng;Hu, Sien;Sinha, Rajita;Mazure, Carolyn M.;Li, Chiang-shan R.
通讯作者：
Li, Chiang-shan R.
影响因子：
25.8
作者：
Hu, Yuzheng;Salmeron, Betty Jo;Yang, Yihong
通讯作者：
Yang, Yihong
影响因子：
5.7
作者：
Bolla, KI;Eldreth, DA;Ernst, M
通讯作者：
Ernst, M