Imacon 200 Ultra High-Speed Framing Camera System

Imacon 200 超高速分幅相机系统

• 批准号: 6731470
• 负责人: LAWRENCE A CRUM
• 金额: $ 38.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6731470
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; image processing; photography; ultrasound

DESCRIPTION (provided by applicant): The purpose of this application is to obtain funding to purchase an Imacon 200 high-speed camera system to be shared by 10 users (from 5 Universities) to pursue projects from 7 funded NIH grants. Our team of investigators conducts clinically relevant basic research of therapeutic and diagnostic ultrasound. Much of the work involves acoustic cavitation -- the formation, growth and violent collapse of bubbles -- on the scale of nanoseconds to milliseconds. Various tools are available for cavitation detection and quantification, but none is more powerful for visualizing bubbles in water than high-speed photography. We have managed to fund 3 brief rental periods during which we have collected data for 11 published papers. The Imacon 200 is the only camera capable of the spatial and temporal resolution, number of frames, and flexibility of adjustable inter-frame spacing required by our studies, but it is not for rent. The Imacon 200 will be available for shared use under the direction of the Camera Supervisor Dr. Lawrence Crum. Drs. Crum and Michael Bailey will use the camera to capture the shock wave interactions of the dual pulse lithotripter to characterize the lithotripter for potential in vivo use. Drs. Thomas Matula and Crum will image the response and rupture of echo contrast agents to identify acoustic parameters to optimize ultrasound image resolution. Dr. Tim Colonius plans to utilize camera images to verify a newly developed numerical predictor of bubble dynamics. Dr. Robin Cleveland looks to capture the acoustics and cavitation fields of new 3rd-generation lithotripters in an effort to correlate these characteristics with a recent decline in lithotripter efficacy and safety. Drs. Clyde Briant and Cleveland will investigate the rapid process of fracture in kidney stones. Dr. James McAteer will use the camera to find optimal parameters of voltage and rate of shock wave delivery in lithotripsy and Drs. James Williams and McAteer will record cavitation behavior in vitro under conditions that simulate the environment of the renal pelvis and kidney blood vessels to assess mechanisms of collateral damage in lithotripsy. Dr. Andrew Evan will observe cavitation activity in the kidney collecting system in vivo. Dr. Roy Martin hopes to capture the entrainment of bubbles, emulsification of blood, and the formation of a hemostatic paste in work to develop HIFU as a practical tool for trauma and surgical care.

描述（由申请人提供）： 此应用程序的目的是获得资金购买Imacon 200高速摄像机系统，由10个用户（来自5所大学）共享，以进行7个NIH赠款项目。我们的研究团队进行临床相关的治疗和诊断超声基础研究。大部分的工作都涉及到声空化--气泡的形成、增长和猛烈的破裂--在纳秒到毫秒的尺度上。有各种工具可用于空化检测和量化，但没有一种工具比高速摄影更能可视化水中的气泡。我们已经成功地资助了3个短暂的租赁期，在此期间，我们收集了11篇已发表论文的数据。Imacon 200是唯一一款能够满足我们研究所需的空间和时间分辨率、帧数以及可调节帧间间距的灵活性的相机，但它不是出租的。Imacon 200将在摄像机主管Lawrence Crum博士的指导下共享使用。Crum和Michael Bailey医生将使用摄像机捕捉双脉冲碎石机的冲击波相互作用，以表征碎石机的潜在体内使用。托马斯Matula和Crum博士将对回声造影剂的反应和破裂进行成像，以识别声学参数，从而优化超声图像分辨率。Tim Colonius博士计划利用相机图像来验证新开发的气泡动力学数值预测器。Robin Cleveland博士希望捕捉新的第三代碎石机的声学和空化场，以将这些特征与最近碎石机有效性和安全性的下降相关联。克莱德布里昂特和克利夫兰博士将研究肾结石骨折的快速过程。James McAteer博士将使用摄像机寻找碎石术中冲击波输送的电压和速率的最佳参数，James威廉姆斯博士和McAteer博士将在模拟肾盂和肾血管环境的条件下记录体外空化行为，以评估碎石术中附带损伤的机制。Andrew Evan博士将在体内观察肾脏收集系统中的空化活动。Roy Martin博士希望在工作中捕获气泡的夹带、血液的乳化和止血膏的形成，以开发HIFU作为创伤和外科护理的实用工具。