Ultrasound-Guided HIFU for Tumor Treatment

超声引导下 HIFU 肿瘤治疗

• 批准号: 7227736
• 负责人: LAWRENCE A CRUM
• 金额: $ 48.36万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-27 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7227736
• 关键词: 3-Dimensional; Ablation; Acoustics; Acute; Address; Algorithms; Biology; Characteristics; China; Clinical; Clinical Trials; Color; Communication; Computer software; Data; Detection; Development; Devices; Distant; Dose; Effectiveness; Elements; Engineering; Equipment; Europe; Evolution; Family suidae; Feedback; Financial compensation; Focused Ultrasound Therapy; Frequencies; Funding; Future; Goals; Government; Heating; Hemostatic function; Image; In Situ; In Vitro; International; Investigation; Knowledge; Lesion; Life; Link; Literature; Liver; Location; Marketing; Mathematics; Measurement; Medical; Medicine; Methods; Modality; Modeling; Monitor; Morphology; Motion; Motivation; Numbers; Operative Surgical Procedures; Output; Paper; Patients; Physics; Placement; Positioning Attribute; Process; Property; Protocols documentation; Publishing; Radiation; Radio; Range; Reflex action; Relative (related person); Research; Research Personnel; Resolution; Robotics; Role; Scanning; Series; Shapes; Simulate; Site; Societies; Software Engineering; Solid; Source; System; Techniques; Technology; Temperature; Temperature Sense; Testing; Tetradecanoylphorbol Acetate; Therapeutic; Therapeutic Studies; Time; Tissues; Treatment Protocols; Ultrasonic Transducer; Ultrasonography; United States Food and Drug Administration; Update; Water; base; c new; cancer therapy; computerized data processing; data acquisition; design; desire; dosimetry; experience; image processing; image registration; in vivo; instrument; interest; models and simulation; multidisciplinary; performance tests; programs; prototype; research study; response; software development; symposium; technology development; time use; tissue phantom; transmission process; treatment planning; tumor

DESCRIPTION (provided by applicant): Thermal therapies have important applications in cancer treatment; viz., curative or palliative tumor ablation. High intensity focused ultrasound (HIFU) is an attractive modality for such applications because of its potential to be applied non-invasively (i.e., transcutaneously). Several factors limit the effectiveness of HIFU therapy; viz., the abilities to:(1) develop effective treatment protocols based on a firm understanding of the physics and biology, (2) monitor treatment progression in real time to provide guidance and control, (3) deliver the appropriate thermal dose accurately and efficiently, and (4) register the target and compensate for tissue motion. The project's long term objective is to develop an integrated thermal therapy research system that uses transcutaneous HIFU as the heat source and which would serve as a prototype for future therapy platforms. Specific aims address the needs identified above, development of a research therapy system, and preliminary testing of the system in vivo. Aim 1 is to develop quantitative approaches to HIFU exposimetry and thermal dosimetry, and to validate and refine them for treatment planning. Aim 2 is to refine our algorithms for processing radio frequency ultrasound (US) backscatter data to enable real time monitoring and control of treatment progression produced using HIFU or other thermal therapies. Aim 3 is to develop new HIFU protocols using continuously moving focal zones to produce desired volumetric tissue temperature profiles and lesion geometries, and thus enable accurate and efficient treatment. Although cavitation is often associated with HIFU and can ablate tissues mechanically, we will attempt to devise protocols that minimize its role. Aim 4 is to refine algorithms for pre-treatment multimode image registration (e.g., MR and 3-D US) and for motion compensation using time-of-treatment 2-D US images, and to integrate these algorithms with the HIFU therapy plan, US temperature sensing, and a simple robotic system to build a research US-guided therapy system. Aim 5 is to test the system in acute studies of lesion placement in vivo, and to iteratively refine the system components. A multidisciplinary team approach is taken, involving acoustics, biology, medicine, applied mathematics, engineering, and software development, and will build on a large collective experience with HIFU technology. In vitro and in vivo experimentation, numerical modeling, image processing methods and other engineering aspects will contribute to the overall goal, with close communication between elements to enable rapid feedback and refinements.

描述（由申请人提供）： 热疗法在癌症治疗中具有重要应用；即，治愈性或姑息性肿瘤消融。高强度聚焦超声（HIFU）对于此类应用来说是一种有吸引力的方式，因为它具有非侵入性（即经皮）应用的潜力。有几个因素限制了 HIFU 治疗的有效性；即，具有以下能力：（1）基于对物理和生物学的深入理解制定有效的治疗方案，（2）实时监测治疗进展以提供指导和控制，（3）准确有效地提供适当的热剂量，以及（4）记录目标并补偿组织运动。该项目的长期目标是开发一种综合热疗研究系统，该系统使用经皮 HIFU 作为热源，并将作为未来治疗平台的原型。具体目标是解决上述需求、开发研究治疗系统以及对该系统进行体内初步测试。目标 1 是开发 HIFU 暴露测定和热剂量测定的定量方法，并验证和完善它们以用于治疗计划。目标 2 是完善我们处理射频超声 (US) 反向散射数据的算法，以便能够实时监测和控制使用 HIFU 或其他热疗法产生的治疗进展。目标 3 是开发新的 HIFU 协议，使用连续移动的聚焦区域来产生所需的体积组织温度分布和病变几何形状，从而实现准确和高效的治疗。尽管空化通常与 HIFU 相关并且可以机械消融组织，但我们将尝试设计尽量减少其作用的方案。目标 4 是改进治疗前多模式图像配准（例如 MR 和 3-D US）以及使用治疗时 2-D US 图像进行运动补偿的算法，并将这些算法与 HIFU 治疗计划、US 温度传感和简单的机器人系统集成，以构建研究型 US 引导治疗系统。目标 5 是在体内病变放置的急性研究中测试该系统，并迭代完善系统组件。采用多学科团队方法，涉及声学、生物学、医学、应用数学、工程和软件开发，并将建立在 HIFU 技术的大量集体经验的基础上。体外和体内实验、数值建模、图像处理方法和其他工程方面将有助于实现总体目标，各要素之间密切沟通，以实现快速反馈和改进。